Rohan T Baker
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Explore the profile of Rohan T Baker including associated specialties, affiliations and a list of published articles.
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20
Citations
1081
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Recent Articles
1.
Murray D, Baker R, Gaur S, Young G, Pedersen S
J Appl Lab Med
. 2020 Jul;
2(2):165-175.
PMID: 32630973
Background: Colvera™ is a test that detects circulating tumor-derived DNA in patients with colorectal cancer by assaying for the presence of methylated BCAT1 and IKZF1 in blood. This study describes...
2.
Symonds E, Pedersen S, Murray D, Jedi M, Byrne S, Rabbitt P, et al.
Clin Epigenetics
. 2018 May;
10:63.
PMID: 29796114
Background: Cell-free circulating tumour-derived DNA (ctDNA) can be detected by testing for methylated and DNA, which has proven sensitivity for colorectal cancer (CRC). A prospective correlative biomarker study between presence...
3.
Mitchell S, Ho T, Brown G, Baker R, Thomas M, McEvoy A, et al.
Genes (Basel)
. 2016 Dec;
7(12).
PMID: 27983717
Solid tumors shed DNA into circulation, and there is growing evidence that the detection of circulating tumor DNA (ctDNA) has broad clinical utility, including monitoring of disease, prognosis, response to...
4.
Young G, Pedersen S, Mansfield S, Murray D, Baker R, Rabbitt P, et al.
Cancer Med
. 2016 Oct;
5(10):2763-2772.
PMID: 27726312
Recurrence will develop in 30-50% of colorectal cancer (CRC) cases despite apparent clearance following treatment. Carcinoembryonic antigen (CEA) is the only guideline-recommended blood test for monitoring cases for recurrence, but...
5.
Symonds E, Pedersen S, Baker R, Murray D, Gaur S, Cole S, et al.
Clin Transl Gastroenterol
. 2016 Jan;
7:e137.
PMID: 26765125
Objectives: To compare the performance of a new blood test for colorectal cancer (CRC) to an established fecal immunochemical test (FIT) in a study population with the full range of...
6.
Pedersen S, Symonds E, Baker R, Murray D, McEvoy A, van Doorn S, et al.
BMC Cancer
. 2015 Oct;
15:654.
PMID: 26445409
Background: Specific genes, such as BCAT1 and IKZF1, are methylated with high frequency in colorectal cancer (CRC) tissue compared to normal colon tissue specimens. Such DNA may leak into blood...
7.
Pedersen S, Baker R, McEvoy A, Murray D, Thomas M, Molloy P, et al.
PLoS One
. 2015 May;
10(4):e0125041.
PMID: 25928810
Background: Specific genes are methylated with high frequency in colorectal neoplasia, and may leak into blood. Detection of multiple methylated DNA biomarkers in blood may improve assay sensitivity for colorectal...
8.
Pedersen S, Mitchell S, Graham L, McEvoy A, Thomas M, Baker R, et al.
Epigenetics
. 2014 May;
9(8):1071-82.
PMID: 24799664
The CAHM gene (Colorectal Adenocarcinoma HyperMethylated), previously LOC100526820, is located on chromosome 6, hg19 chr6:163 834 097-163 834 982. It lacks introns, encodes a long non-coding RNA (lncRNA) and is...
9.
Mitchell S, Ross J, Drew H, Ho T, Brown G, Saunders N, et al.
BMC Cancer
. 2014 Feb;
14:54.
PMID: 24485021
Background: The development of colorectal cancer (CRC) is accompanied by extensive epigenetic changes, including frequent regional hypermethylation particularly of gene promoter regions. Specific genes, including SEPT9, VIM1 and TMEFF2 become...
10.
Singhal S, Taylor M, Baker R
BMC Biochem
. 2008 Nov;
9 Suppl 1:S3.
PMID: 19007433
Deubiquitylating enzymes (DUBs) can hydrolyze a peptide, amide, ester or thiolester bond at the C-terminus of UBIQ (ubiquitin), including the post-translationally formed branched peptide bonds in mono- or multi-ubiquitylated conjugates....