Roger M Benoit
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Explore the profile of Roger M Benoit including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
250
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Recent Articles
1.
Gupta R, Scharer P, Liao Y, Roy B, Benoit R, Shivashankar G
Mol Biol Cell
. 2025 Feb;
36(4):ar37.
PMID: 39908115
The tumor microenvironment (TME) is a dynamic ecosystem, that evolves with the developing tumor to support its growth and metastasis. A key aspect of TME evolution is the recruitment of...
2.
Farnung J, Muhar M, Liang J, Tolmachova K, Benoit R, Corn J, et al.
ACS Cent Sci
. 2023 May;
9(5):1025-1034.
PMID: 37252361
Macroautophagy is one of two major degradation systems in eukaryotic cells. Regulation and control of autophagy are often achieved through the presence of short peptide sequences called LC3 interacting regions...
3.
Collu G, Bierig T, Krebs A, Engilberge S, Varma N, Guixa-Gonzalez R, et al.
Structure
. 2021 Sep;
30(1):95-106.e7.
PMID: 34587504
Chimeric fusion proteins are essential tools for protein nanotechnology. Non-optimized protein-protein connections are usually flexible and therefore unsuitable as structural building blocks. Here we show that the ER/K motif, a...
4.
Bierig T, Collu G, Blanc A, Poghosyan E, Benoit R
Front Bioeng Biotechnol
. 2021 Jan;
8:618615.
PMID: 33409271
2019-nCoV is the causative agent of the serious, still ongoing, worldwide coronavirus disease (COVID-19) pandemic. High quality recombinant virus proteins are required for research related to the development of vaccines...
5.
Skopintsev P, Ehrenberg D, Weinert T, James D, Kar R, Johnson P, et al.
Nature
. 2020 Jun;
583(7815):314-318.
PMID: 32499654
Light-driven sodium pumps actively transport small cations across cellular membranes. These pumps are used by microorganisms to convert light into membrane potential and have become useful optogenetic tools with applications...
6.
Krebs A, Bierig T, Collu G, Benoit R
Plasmid
. 2019 Nov;
106:102445.
PMID: 31669339
The engineering of fusion proteins for structural biology and protein nanotechnology often requires seamless DNA assembly with slight variations in the domain boundaries. To improve the molecular biology workflow for...
7.
Benoit R
Toxins (Basel)
. 2018 Aug;
10(8).
PMID: 30071587
Botulinum neurotoxins (BoNTs) rank amongst the most potent toxins known. The factors responsible for the emergence of the many known and yet unknown BoNT variants remain elusive. It also remains...
8.
Benoit R, Scharer M, Wieser M, Li X, Frey D, Kammerer R
Sci Rep
. 2017 Mar;
7:43588.
PMID: 28252640
A detailed molecular understanding of botulinum neurotoxin (BoNT)/host-cell-receptor interactions is fundamental both for developing strategies against botulism and for generating improved BoNT variants for medical applications. The X-ray crystal structure...
9.
Bianchi S, van Riel W, Kraatz S, Olieric N, Frey D, Katrukha E, et al.
Sci Rep
. 2016 Aug;
6:30668.
PMID: 27485312
Tight regulation of kinesin activity is crucial and malfunction is linked to neurological diseases. Point mutations in the KIF21A gene cause congenital fibrosis of the extraocular muscles type 1 (CFEOM1)...
10.
Benoit R, Ostermeier C, Geiser M, Li J, Widmer H, Auer M
PLoS One
. 2016 Apr;
11(4):e0153158.
PMID: 27073895
Seamless cloning methods, such as co-transformation cloning, sequence- and ligation-independent cloning (SLIC) or the Gibson assembly, are essential tools for the precise construction of plasmids. The efficiency of co-transformation cloning...