Richard A Kammerer
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Explore the profile of Richard A Kammerer including associated specialties, affiliations and a list of published articles.
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66
Citations
1680
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Recent Articles
1.
Khanppnavar B, Leka O, Pal S, Korkhov V, Kammerer R
Nat Commun
. 2025 Feb;
16(1):1224.
PMID: 39934119
Botulinum neurotoxin A1 (BoNT/A1) belongs to the most potent toxins and is used as a major therapeutic agent. Neurotoxin conformation is crucial for its translocation to the neuronal cytosol, a...
2.
Khanppnavar B, Choo J, Hagedoorn P, Smolentsev G, Stefanic S, Kumaran S, et al.
Nat Chem
. 2024 May;
16(9):1496-1504.
PMID: 38744914
Membrane-bound styrene oxide isomerase (SOI) catalyses the Meinwald rearrangement-a Lewis-acid-catalysed isomerization of an epoxide to a carbonyl compound-and has been used in single and cascade reactions. However, the structural information...
3.
Leka O, Wu Y, Zanetti G, Furler S, Reinberg T, Marinho J, et al.
Nat Commun
. 2023 Dec;
14(1):8317.
PMID: 38110403
In this study, we characterize Designed Ankyrin Repeat Proteins (DARPins) as investigative tools to probe botulinum neurotoxin A1 (BoNT/A1) structure and function. We identify DARPin-F5 that completely blocks SNAP25 substrate...
4.
Seo D, Kammerer R, Alexandrescu A
Biomol NMR Assign
. 2023 Oct;
17(2):301-307.
PMID: 37861970
Kinesin is a motor protein, comprised of two heavy and two light chains that transports cargo along the cytoskeletal microtubule filament network. The heavy chain has a neck domain connecting...
5.
Amer M, Leka O, Jasko P, Frey D, Li X, Kammerer R
Sci Rep
. 2023 Jun;
13(1):10159.
PMID: 37349348
Structure elucidation of inactive-state GPCRs still mostly relies on X-ray crystallography. The major goal of our work was to create a new GPCR tool that would provide receptor stability and...
6.
Trebosc V, Lucchini V, Narwal M, Wicki B, Gartenmann S, Schellhorn B, et al.
Virulence
. 2022 Oct;
13(1):1868-1883.
PMID: 36261919
The development of anti-virulence drug therapy against infections would provide an alternative to traditional antibacterial therapy that are increasingly failing. Here, we demonstrate that the OmpR transcriptional regulator plays a...
7.
Nass K, Ilie I, Saller M, Driessen A, Caflisch A, Kammerer R, et al.
Biochim Biophys Acta Biomembr
. 2021 Dec;
1864(3):183825.
PMID: 34871574
The evolutionary conserved YidC is a unique dual-function membrane protein that adopts insertase and chaperone conformations. The N-terminal helix of Escherichia coli YidC functions as an uncleaved signal sequence and...
8.
Leka O, Wu Y, Li X, Kammerer R
J Biol Chem
. 2021 Apr;
296:100684.
PMID: 33891946
Botulinum neurotoxins (BoNTs) are among the most widely used therapeutic proteins; however, only two subtypes within the seven serotypes, BoNT/A1 and BoNT/B1, are currently used for medical and cosmetic applications....
9.
Fiedler T, Ndinyanka Fabrice T, Studer V, Vinet A, Faltova L, Kammerer R, et al.
FEBS Lett
. 2020 Apr;
PMID: 32298460
Coronin proteins are widely expressed among eukaryotic organisms. Most coronins consist of a WD-repeat domain followed by a C-terminal coiled coil. Dictyostelium discoideum expresses a single short coronin coronin A,...
10.
Li X, Brunner C, Wu Y, Leka O, Schneider G, Kammerer R
Toxicon
. 2019 Nov;
175:36-43.
PMID: 31783045
A dual-receptor interaction with a polysialoganglioside and synaptic vesicle glycoprotein 2 (SV2) is required for botulinum neurotoxin A (BoNT) toxicity. Here, we review what is currently known about the BoNT/A-SV2...