Roger J Liang
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Explore the profile of Roger J Liang including associated specialties, affiliations and a list of published articles.
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12
Citations
335
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Recent Articles
1.
Langer H, Ramsamooj S, Dantas E, Murthy A, Ahmed M, Ahmed T, et al.
Acta Physiol (Oxf)
. 2024 May;
240(8):e14167.
PMID: 38779820
Aim: To investigate systemic regulators of the cancer-associated cachexia syndrome (CACS) in a pre-clinical model for lung cancer with the goal to identify therapeutic targets for tissue wasting. Methods: Using...
2.
Langer H, Ramsamooj S, Dantas E, Murthy A, Ahmed M, Hwang S, et al.
bioRxiv
. 2023 Aug;
PMID: 37577571
The cancer associated cachexia syndrome (CACS) is a systemic metabolic disorder resulting in loss of body weight due to skeletal muscle and adipose tissues atrophy. CACS is particularly prominent in...
3.
Romano G, Paradiso F, Li P, Shukla P, Barger L, El Naggar O, et al.
Cancer Immunol Res
. 2023 Feb;
11(5):558-569.
PMID: 36820825
Patients with BRAF-mutant melanoma show substantial responses to combined BRAF and MEK inhibition, but most relapse within 2 years. A major reservoir for drug resistance is minimal residual disease (MRD),...
4.
Stein B, Ferrarone J, Gardner E, Chang J, Wu D, Hollstein P, et al.
Cancer Discov
. 2023 Jan;
13(4):1002-1025.
PMID: 36715544
Significance: Utilizing phosphoproteomics and metabolomics in genetically engineered human cell lines and genetically engineered mouse models (GEMM), we uncover an evolutionary divergence in metabolic regulation within a clinically relevant genotype...
5.
Queiroz A, Dantas E, Ramsamooj S, Murthy A, Ahmed M, Zunica E, et al.
Nat Commun
. 2022 Aug;
13(1):4633.
PMID: 35941104
Cancer cachexia is a common, debilitating condition with limited therapeutic options. Using an established mouse model of lung cancer, we find that cachexia is characterized by reduced food intake, spontaneous...
6.
Langer H, Ramsamooj S, Liang R, Grover R, Hwang S, Dasilva Goncalves M
Front Oncol
. 2022 Jun;
12:903157.
PMID: 35719965
Cachexia is a debilitating comorbidity affecting many lung cancer patients. We have previously found that cachectic mice with lung cancer have reduced serum ketone body levels due to low PPARα...
7.
Taylor S, Ramsamooj S, Liang R, Katti A, Pozovskiy R, Vasan N, et al.
Nature
. 2021 Aug;
597(7875):263-267.
PMID: 34408323
Fructose consumption is linked to the rising incidence of obesity and cancer, which are two of the leading causes of morbidity and mortality globally. Dietary fructose metabolism begins at the...
8.
Liang R, Taylor S, Nahiyaan N, Song J, Murphy C, Dantas E, et al.
Cancer Metab
. 2021 Mar;
9(1):12.
PMID: 33762003
Background: Fructose is an abundant source of carbon and energy for cells to use for metabolism, but only certain cell types use fructose to proliferate. Tumor cells that acquire the...
9.
Torres-Ayuso P, An E, Nyswaner K, Bensen R, Ritt D, Specht S, et al.
Cancer Discov
. 2021 Jan;
11(6):1411-1423.
PMID: 33495197
Lung squamous cell carcinoma (LSCC) is the second most prevalent type of lung cancer. Despite extensive genomic characterization, no targeted therapies are approved for the treatment of LSCC. Distal amplification...
10.
Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang R, et al.
Cancer Discov
. 2020 Jun;
10(9):1352-1373.
PMID: 32571778
A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic constraints imposed by the serine and glycine-limited brain environment restrict metastatic tumor growth. How brain metastases...