Roger H Reeves
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Explore the profile of Roger H Reeves including associated specialties, affiliations and a list of published articles.
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Recent Articles
21.
Brose R, Lehrmann E, Zhang Y, Reeves R, Smith K, Mattson M
Neurobiol Aging
. 2018 Sep;
72:121-133.
PMID: 30245242
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by accumulation of amyloid β-peptide (Aβ) plaques in the brain and decreased cognitive function leading to dementia. We tested if hydroxyurea...
22.
Edie S, Zaghloul N, Leitch C, Klinedinst D, Lebron J, Thole J, et al.
G3 (Bethesda)
. 2018 May;
8(7):2215-2223.
PMID: 29760202
Trisomy for human chromosome 21 (Hsa21) results in Down syndrome (DS), one of the most genetically complex conditions compatible with human survival. Assessment of the physiological consequences of dosage-driven overexpression...
23.
Rambo-Martin B, Mulle J, Cutler D, Bean L, Rosser T, Dooley K, et al.
G3 (Bethesda)
. 2017 Nov;
8(1):105-111.
PMID: 29141989
One in five people with Down syndrome (DS) are born with an atrioventricular septal defect (AVSD), an incidence 2000 times higher than in the euploid population. The genetic loci that...
24.
Starbuck J, Cole 3rd T, Reeves R, Richtsmeier J
Am J Med Genet A
. 2017 Sep;
173(11):2861-2872.
PMID: 28941128
Triplication of chromosome 21 (trisomy 21) results in Down syndrome (DS), the most common live-born human aneuploidy. Individuals with DS have a unique facial appearance that can include form changes...
25.
Edgin J, Anand P, Rosser T, Pierpont E, Figueroa C, Hamilton D, et al.
Am J Intellect Dev Disabil
. 2017 Apr;
122(3):215-234.
PMID: 28452581
A multisite study investigated the test-retest reliability and practice effects of a battery of assessments to measure neurocognitive function in individuals with Down syndrome (DS). The study aimed to establish...
26.
Xiao M, Xu D, Craig M, Pelkey K, Chien C, Shi Y, et al.
Elife
. 2017 Apr;
6.
PMID: 28440221
Memory loss in Alzheimer's disease (AD) is attributed to pervasive weakening and loss of synapses. Here, we present findings supporting a special role for excitatory synapses connecting pyramidal neurons of...
27.
Smith-Hicks C, Cai P, Savonenko A, Reeves R, Worley P
Front Neural Circuits
. 2017 Feb;
11:6.
PMID: 28217086
Down syndrome (DS) is the leading chromosomal cause of intellectual disability, yet the neural substrates of learning and memory deficits remain poorly understood. Here, we interrogate neural networks linked to...
28.
Xiang J, Yang S, Xin N, Gaertig M, Reeves R, Li S, et al.
Proc Natl Acad Sci U S A
. 2017 Feb;
114(7):E1224-E1233.
PMID: 28137862
Huntingtin-associated protein 1 (Hap1) is known to be critical for postnatal hypothalamic function and growth. Hap1 forms stigmoid bodies (SBs), unique neuronal cytoplasmic inclusions of unknown function that are enriched...
29.
30.
Burnicka-Turek O, Steimle J, Huang W, Felker L, Kamp A, Kweon J, et al.
Hum Mol Genet
. 2016 Jun;
25(14):3011-3028.
PMID: 27340223
Atrioventricular septal defects (AVSDs) are a common severe form of congenital heart disease (CHD). In this study we identified deleterious non-synonymous mutations in two cilia genes, Dnah11 and Mks1, in...