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Rodrigo Alvear-Perez

Explore the profile of Rodrigo Alvear-Perez including associated specialties, affiliations and a list of published articles. Areas
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Articles 16
Citations 274
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Recent Articles
1.
Avila-Gutierrez K, Slaoui L, Alvear-Perez R, Kozlowski E, Oudart M, Augustin E, et al.
Glia . 2024 Jan; 72(4):777-793. PMID: 38189217
Astrocytes are highly ramified and send out perivascular processes (PvAPs) that entirely sheathe the brain's blood vessels. PvAPs are equipped with an enriched molecular repertoire that sustains astrocytic regulatory functions...
2.
Gilbert A, Elorza-Vidal X, Rancillac A, Chagnot A, Yetim M, Hingot V, et al.
Elife . 2021 Nov; 10. PMID: 34723793
Absence of the astrocyte-specific membrane protein MLC1 is responsible for megalencephalic leukoencephalopathy with subcortical cysts (MLC), a rare type of leukodystrophy characterized by early-onset macrocephaly and progressive white matter vacuolation...
3.
Flahault A, Girault-Sotias P, Keck M, Alvear-Perez R, De Mota N, Esteoulle L, et al.
Nat Commun . 2021 Jan; 12(1):305. PMID: 33436646
Apelin and arginine-vasopressin (AVP) are conversely regulated by osmotic stimuli. We therefore hypothesized that activating the apelin receptor (apelin-R) with LIT01-196, a metabolically stable apelin-17 analog, may be beneficial for...
4.
Cohen-Salmon M, Slaoui L, Mazare N, Gilbert A, Oudart M, Alvear-Perez R, et al.
Glia . 2020 Oct; 69(4):817-841. PMID: 33058289
Astrocytes are the most numerous type of neuroglia in the brain and have a predominant influence on the cerebrovascular system; they control perivascular homeostasis, the integrity of the blood-brain barrier,...
5.
Flahault A, Couvineau P, Alvear-Perez R, Iturrioz X, Llorens-Cortes C
Front Endocrinol (Lausanne) . 2017 Jun; 8:120. PMID: 28620355
Apelin, a (neuro)vasoactive peptide, plays a prominent role in controlling body fluid homeostasis and cardiovascular functions. In animal models, experimental data demonstrate that intracerebroventricular injection of apelin into lactating rats...
6.
Gerbier R, Alvear-Perez R, Margathe J, Flahault A, Couvineau P, Gao J, et al.
FASEB J . 2016 Nov; 31(2):687-700. PMID: 27815337
Apelin, a (neuro)vasoactive peptide, plays a prominent role in controlling cardiovascular functions and water balance. Because the in vivo apelin half-life is in the minute range, we aimed to identify...
7.
Friis K, Iturrioz X, Thomsen J, Alvear-Perez R, Bahrami S, Llorens-Cortes C, et al.
J Virol . 2015 Nov; 90(3):1647-56. PMID: 26608314
Unlabelled: We have previously reported the construction of a murine leukemia virus-based replication-competent gammaretrovirus (SL3-AP) capable of utilizing the human G protein-coupled receptor APJ (hAPJ) as its entry receptor and...
8.
Gerbier R, Leroux V, Couvineau P, Alvear-Perez R, Maigret B, Llorens-Cortes C, et al.
FASEB J . 2014 Nov; 29(1):314-22. PMID: 25359495
Apelin is the endogenous ligand of the orphan 7-transmembrane domain GPCR APJ, now named the apelin receptor (ApelinR). Apelin plays a prominent role in body fluid and cardiovascular homeostasis. To...
9.
Ceraudo E, Galanth C, Carpentier E, Banegas-Font I, Schonegge A, Alvear-Perez R, et al.
J Biol Chem . 2014 Jul; 289(35):24599-610. PMID: 25012663
Apelin plays a prominent role in body fluid and cardiovascular homeostasis. We previously showed that the C-terminal Phe of apelin 17 (K17F) is crucial for triggering apelin receptor internalization and...
10.
Margathe J, Iturrioz X, Alvear-Perez R, Marsol C, Riche S, Chabane H, et al.
J Med Chem . 2014 Mar; 57(7):2908-19. PMID: 24625069
Apelin is the endogenous ligand for the previously orphaned G protein-coupled receptor APJ. Apelin and its receptor are widely distributed in the brain, heart, and vasculature, and are emerging as...