Rodrigo A Grandy
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Explore the profile of Rodrigo A Grandy including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
171
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Recent Articles
1.
Eldridge C, Allen F, Crisp A, Grandy R, Vallier L, Sale J
Stem Cell Reports
. 2020 Sep;
15(4):827-835.
PMID: 32888504
The ability of human induced pluripotent stem cells (hiPSCs) to differentiate in vitro to each of the three germ layer lineages has made them an important model of early human...
2.
Canu G, Athanasiadis E, Grandy R, Garcia-Bernardo J, Strzelecka P, Vallier L, et al.
Genome Biol
. 2020 Jul;
21(1):157.
PMID: 32611441
Background: Haematopoietic stem cells (HSCs) first arise during development in the aorta-gonad-mesonephros (AGM) region of the embryo from a population of haemogenic endothelial cells which undergo endothelial-to-haematopoietic transition (EHT). Despite...
3.
Yiangou L, Grandy R, Osnato A, Ortmann D, Sinha S, Vallier L
J Biol Chem
. 2019 Sep;
294(47):17903-17914.
PMID: 31515269
The mesoderm is one of the three germ layers produced during gastrulation from which muscle, bones, kidneys, and the cardiovascular system originate. Understanding the mechanisms that control mesoderm specification could...
4.
Yiangou L, Grandy R, Morell C, Tomaz R, Osnato A, Kadiwala J, et al.
Stem Cell Reports
. 2019 Jan;
12(1):165-179.
PMID: 30595546
Cell cycle progression and cell fate decisions are closely linked in human pluripotent stem cells (hPSCs). However, the study of these interplays at the molecular level remains challenging due to...
5.
VanOudenhove J, Grandy R, Ghule P, Lian J, Stein J, Zaidi S, et al.
J Cell Physiol
. 2016 Aug;
232(6):1254-1257.
PMID: 27532275
The cell cycle in pluripotent human embryonic stem cells is governed by unique mechanisms that support unrestricted proliferation and competency for endodermal, mesodermal, and ectodermal differentiation. The abbreviated G1 period...
6.
Van Oudenhove J, Grandy R, Ghule P, Del Rio R, Lian J, Stein J, et al.
Stem Cells
. 2016 Mar;
34(7):1765-75.
PMID: 26946228
Human embryonic stem cells (hESCs) have an abbreviated G1 phase of the cell cycle that allows rapid proliferation and maintenance of pluripotency. Lengthening of G1 corresponds to loss of pluripotency...
7.
Zaidi S, Boyd J, Grandy R, Medina R, Lian J, Stein G, et al.
J Cell Physiol
. 2016 Jan;
231(9):2007-13.
PMID: 26755341
Embryonic stem cells (ESCs) exhibit unrestricted and indefinite, but stringently controlled, proliferation, and can differentiate into any lineage in the body. In the current study, we test the hypothesis that...
8.
Grandy R, Whitfield T, Wu H, Fitzgerald M, VanOudenhove J, Zaidi S, et al.
Mol Cell Biol
. 2015 Dec;
36(4):615-27.
PMID: 26644406
Stem cell phenotypes are reflected by posttranslational histone modifications, and this chromatin-related memory must be mitotically inherited to maintain cell identity through proliferative expansion. In human embryonic stem cells (hESCs),...
9.
Zaidi S, Grandy R, Lopez-Camacho C, Montecino M, van Wijnen A, Lian J, et al.
Cancer Res
. 2014 Jan;
74(2):420-5.
PMID: 24408924
The regulatory information for phenotype, proliferation, and growth of normal and tumor cells must be maintained through genome replication in the S phase and cell division during mitosis. Epigenetic mechanisms...
10.
Tai P, Zaidi S, Wu H, Grandy R, Montecino M, van Wijnen A, et al.
J Cell Physiol
. 2013 Nov;
229(6):711-27.
PMID: 24242872
Compaction of the eukaryotic genome into the confined space of the cell nucleus must occur faithfully throughout each cell cycle to retain gene expression fidelity. For decades, experimental limitations to...