Roderick A F MacLeod
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Explore the profile of Roderick A F MacLeod including associated specialties, affiliations and a list of published articles.
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108
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2405
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Recent Articles
1.
Nagel S, Haake J, Pommerenke C, Meyer C, MacLeod R
Int J Mol Sci
. 2024 Jan;
25(1).
PMID: 38203204
T-box genes encode transcription factors, which control developmental processes and promote cancer if deregulated. Recently, we described the lymphoid TBX-code, which collates T-box gene activities in normal lymphopoiesis, enabling identification...
2.
Nagel S, Pommerenke C, Meyer C, Kaufmann M, MacLeod R
Biomedicines
. 2023 Jun;
11(6).
PMID: 37371852
, and are major oncogenes in B-cell lymphoma. Their aberrant activation frequently occurs via chromosomal translocations which juxtapose light or heavy chain immunoglobulin (IG) genes to and or fuse diverse...
3.
Genomic Aberrations Generate Fusion Gene FOXK2::TP63 and Activate NFKB1 in Cutaneous T-Cell Lymphoma
Nagel S, Pommerenke C, Quentmeier H, Meyer C, Kaufmann M, MacLeod R
Biomedicines
. 2022 Aug;
10(8).
PMID: 36009586
Cutaneous T-cell lymphoma (CTCL) is a severe lymphoid malignancy with a worse prognosis lacking curative treatment regimens. Several gene mutations and deregulated pathways, including NFkB signaling, have been implicated in...
4.
Nagel S, Pommerenke C, Meyer C, MacLeod R
Int J Mol Sci
. 2022 Mar;
23(6).
PMID: 35328612
Homeobox genes encode transcription factors that control basic developmental decisions. Knowledge of their hematopoietic activities casts light on normal and malignant immune cell development. Recently, we constructed the so-called lymphoid...
5.
NKL Homeobox Genes NKX2-3 and NKX2-4 Deregulate Megakaryocytic-Erythroid Cell Differentiation in AML
Nagel S, Pommerenke C, Meyer C, MacLeod R
Int J Mol Sci
. 2021 Nov;
22(21).
PMID: 34768865
NKL homeobox genes encode transcription factors that impact normal development and hematopoietic malignancies if deregulated. Recently, we established an NKL-code that describes the physiological expression pattern of eleven NKL homeobox...
6.
Nagel S, Pommerenke C, Meyer C, MacLeod R, Drexler H
PLoS One
. 2021 Feb;
16(2):e0246603.
PMID: 33539429
Homeobox genes encode transcription factors which regulate basic processes in development and cell differentiation and are grouped into classes and subclasses according to sequence similarities. Here, we analyzed the activities...
7.
Nagel S, Pommerenke C, Meyer C, MacLeod R, Drexler H
PLoS One
. 2020 Oct;
15(10):e0240120.
PMID: 33048949
The NKL-code describes normal expression patterns of NKL homeobox genes in hematopoiesis. Aberrant expression of NKL homeobox gene subclass members have been reported in several hematopoietic malignancies including acute myeloid...
8.
Nagel S, Pommerenke C, MacLeod R, Meyer C, Kaufmann M, Drexler H
Oncotarget
. 2020 Sep;
11(34):3208-3226.
PMID: 32922661
NKL homeobox genes encode developmental transcription factors and display an NKL-code according to their physiological expression pattern in hematopoiesis. Here, we analyzed public transcriptome data from primary innate lymphoid cells...
9.
Nagel S, Scherr M, MacLeod R, Pommerenke C, Koeppel M, Meyer C, et al.
PLoS One
. 2019 Dec;
14(12):e0226212.
PMID: 31825998
Recently, we have documented a hematopoietic NKL-code mapping physiological expression patterns of NKL homeobox genes in early hematopoiesis and in lymphopoiesis, which spotlights genes deregulated in lymphoid malignancies. Here, we...
10.
Quentmeier H, Pommerenke C, Dirks W, Eberth S, Koeppel M, MacLeod R, et al.
Sci Rep
. 2019 Jun;
9(1):8218.
PMID: 31160637
For many years, immortalized cell lines have been used as model systems for cancer research. Cell line panels were established for basic research and drug development, but did not cover...