Roderick A F MacLeod
Overview
Explore the profile of Roderick A F MacLeod including associated specialties, affiliations and a list of published articles.
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108
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2405
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Recent Articles
11.
Nagel S, Pommerenke C, MacLeod R, Meyer C, Kaufmann M, Fahnrich S, et al.
Oncotarget
. 2019 May;
10(35):3227-3247.
PMID: 31143370
Recently, we have presented a scheme, termed "NKL-code", which describes physiological expression patterns of NKL homeobox genes in early hematopoiesis and in lymphopoiesis including main stages of T-, B- and...
12.
Nagel S, MacLeod R, Pommerenke C, Meyer C, Kaufmann M, Drexler H
Oncotarget
. 2019 Jan;
9(101):37480-37496.
PMID: 30680064
NKL homeobox genes encode basic transcriptional regulators of cell and tissue differentiation. Recently, we described a hematopoietic NKL-code comprising nine specific NKL homeobox genes expressed in normal hematopoietic stem cells,...
13.
Nagel S, MacLeod R, Meyer C, Kaufmann M, Drexler H
PLoS One
. 2018 Oct;
13(10):e0205537.
PMID: 30308041
Homeobox genes encode transcription factors which regulate basic processes in development and cell differentiation. Several members of the NKL subclass are deregulated in T-cell progenitors and support leukemogenesis. We have...
14.
Nagel S, Meyer C, Kaufmann M, Zaborski M, MacLeod R, Drexler H
PLoS One
. 2018 May;
13(5):e0197194.
PMID: 29746601
T-cell acute lymphoblastic leukemia (T-ALL) is a hematopoietic malignancy originating from T-cell progenitors in which differentiation is blocked at early stages. Physiological expression of specific NKL homeobox genes obeys a...
15.
Nagel S, Pommerenke C, Meyer C, Kaufmann M, MacLeod R, Drexler H
Oncotarget
. 2018 Mar;
9(18):14338-14353.
PMID: 29581848
NKL homeobox genes are basic regulators of cell and tissue differentiation, many acting as oncogenes in T-cell leukemia. Recently, we described an hematopoietic NKL-code comprising six particular NKL homeobox genes...
16.
Ding C, Chen S, MacLeod R, Drexler H, Nagel S, Wu D, et al.
Ups J Med Sci
. 2018 Mar;
123(1):19-27.
PMID: 29493383
Background: Emerging evidence has revealed that miRNAs can function as oncogenes or tumor suppressor genes in leukemia. The ectopic expression of miR-130a has been reported in chronic leukemia, but our...
17.
Chen S, Nagel S, Schneider B, Dai H, Geffers R, Kaufmann M, et al.
Cell Oncol (Dordr)
. 2017 Nov;
41(1):93-101.
PMID: 29119387
Background: Previously, the chromosomal translocation t(12;15)(p13;q25) has been found to recurrently occur in both solid tumors and leukemias. This translocation leads to ETV6-NTRK3 (EN) gene fusions resulting in ectopic expression...
18.
Nagel S, Pommerenke C, Meyer C, Kaufmann M, MacLeod R, Drexler H
Oncotarget
. 2017 Oct;
8(40):66815-66832.
PMID: 28977998
NKL homeobox gene MSX1 is physiologically expressed in lymphoid progenitors and subsequently downregulated in developing T- and B-cells. In contrast, elevated expression levels of MSX1 persist in mature natural killer...
19.
Ehrentraut S, Nagel S, Pommerenke C, Dirks W, Quentmeier H, Kaufmann M, et al.
Haematologica
. 2017 Jun;
102(9):e356-e359.
PMID: 28659334
No abstract available.
20.
Xu X, Nagel S, Quentmeier H, Wang Z, Pommerenke C, Dirks W, et al.
Leuk Lymphoma
. 2017 May;
59(1):204-213.
PMID: 28540746
KDM3B reportedly shows both tumor-suppressive and tumor-promoting activities in leukemia. The function of KDM3B is likely cell-type dependent and its seeming functional discordance may reflect its phenotypic dependence on downstream...