Robin A J Smith
Overview
Explore the profile of Robin A J Smith including associated specialties, affiliations and a list of published articles.
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71
Citations
5169
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Recent Articles
1.
Park M, Nishimura T, Baeza-Garza C, Caldwell S, Pun P, Prag H, et al.
Cardiovasc Drugs Ther
. 2020 Sep;
34(6):823-834.
PMID: 32979176
Purpose: HFpEF (heart failure with preserved ejection fraction) is a major consequence of diabetic cardiomyopathy with no effective treatments. Here, we have characterized Akita mice as a preclinical model of...
2.
Dong L, Jameson V, Tilly D, Prochazka L, Rohlena J, Valis K, et al.
Free Radic Biol Med
. 2018 Sep;
65:895-896.
PMID: 30184722
No abstract available.
3.
Hoogewijs K, James A, Smith R, Abendroth F, Gait M, Murphy M, et al.
Interface Focus
. 2017 Apr;
7(2):20160117.
PMID: 28382203
There is an increasing interest in targeting molecules to the mitochondrial matrix. Many proteins are naturally imported through the translocase complexes found in the outer and inner mitochondrial membranes. One...
4.
Hoogewijs K, James A, Smith R, Gait M, Murphy M, Lightowlers R
Chembiochem
. 2016 Apr;
17(14):1312-6.
PMID: 27124570
Mitochondria are central to health and disease, hence there is considerable interest in developing mitochondria-targeted therapies that require the delivery of peptides or nucleic acid oligomers. However, progress has been...
5.
Smith M, Vayalil P, Zhou F, Benavides G, Beggs R, Golzarian H, et al.
Redox Biol
. 2016 Jan;
8:136-48.
PMID: 26774751
Many cancer cells follow an aberrant metabolic program to maintain energy for rapid cell proliferation. Metabolic reprogramming often involves the upregulation of glutaminolysis to generate reducing equivalents for the electron...
6.
Logan A, Pell V, Shaffer K, Evans C, Stanley N, Robb E, et al.
Cell Metab
. 2015 Dec;
23(2):379-85.
PMID: 26712463
The mitochondrial membrane potential (Δψm) is a major determinant and indicator of cell fate, but it is not possible to assess small changes in Δψm within cells or in vivo....
7.
Jameson V, Cocheme H, Logan A, Hanton L, Smith R, Murphy M
Tetrahedron
. 2015 Nov;
71(44):8444-8453.
PMID: 26549895
A series of mitochondria-targeted antioxidants comprising a lipophilic triphenylphosphonium cation attached to the antioxidant chroman moiety of vitamin E by an alkyl linker have been prepared. The synthesis of a...
8.
Finichiu P, Larsen D, Evans C, Larsen L, Bright T, Robb E, et al.
Free Radic Biol Med
. 2015 Oct;
89:668-78.
PMID: 26453920
Mitochondrial oxidative damage contributes to a wide range of pathologies. One therapeutic strategy to treat these disorders is targeting antioxidants to mitochondria by conjugation to the lipophilic triphenylphosphonium (TPP) cation....
9.
Vayalil P, Oh J, Zhou F, Diers A, Smith M, Golzarian H, et al.
PLoS One
. 2015 Mar;
10(3):e0120460.
PMID: 25785718
Despite advances in screening and treatment over the past several years, breast cancer remains a leading cause of cancer-related death among women in the United States. A major goal in...
10.
Spencer E, Dale E, Gommans A, Rutledge M, Vo C, Nakatani Y, et al.
Eur J Med Chem
. 2015 Mar;
93:501-10.
PMID: 25743213
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has roles in the innate immune response, and also contributes to inflammatory disease. While the biological properties of MIF are...