Robin A J Lester
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Explore the profile of Robin A J Lester including associated specialties, affiliations and a list of published articles.
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11
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340
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Recent Articles
1.
Lester R
Rev Neurosci
. 2011 Jul;
22(4):467-70.
PMID: 21790507
Much of the addictive power of nicotine in humans may be attributable to learned contextual associations, such that these secondary cues become potent predictive incentives for both maintaining and driving...
2.
Penton R, Quick M, Lester R
J Neurosci
. 2011 Feb;
31(7):2584-94.
PMID: 21325526
The potential for relapse following cessation of drug use can last for years, implying the induction of stable changes in neural circuitry. In hippocampal slices from rats treated with nicotine...
3.
Penton R, Lester R
Semin Cell Dev Biol
. 2009 Jun;
20(4):418-31.
PMID: 19560047
In the 25 years since the observation that chronic exposure to nicotine could regulate the number and function of high affinity nicotine binding sites in the brain there has been...
4.
Fonck C, Nashmi R, Salas R, Zhou C, Huang Q, De Biasi M, et al.
Neuropharmacology
. 2008 Sep;
56(1):247-53.
PMID: 18789953
The medial habenula (MHb) exhibits exceptionally high levels of nicotinic acetylcholine receptors (nAChRs), but it remains unclear whether all expressed nAChR subunit mRNAs are translated to form functional receptors. In...
5.
Guo X, Lester R
J Neurophysiol
. 2006 Oct;
97(1):83-92.
PMID: 17050826
The fraction of inward current carried by Ca(2+) (FCa(2+)) through nicotinic acetylcholine receptors (nAChRs) on acutely isolated rat medial habenula (MHb) neurons was calculated from experiments that simultaneously monitored agonist-induced...
6.
Guo X, Lester R
J Neurophysiol
. 2006 Oct;
97(1):93-101.
PMID: 17050825
The relationship between the concentration of intracellular Ca2+ ([Ca2+](i)) and recovery from desensitization of nicotinic acetylcholine receptors (nAChRs) in rat medial habenula (MHb) neurons was investigated using the whole cell...
7.
Cho C, Song W, Leitzell K, Teo E, Meleth A, Quick M, et al.
J Neurosci
. 2005 Apr;
25(14):3712-23.
PMID: 15814802
Alpha7 nicotinic acetylcholine receptors (nAChRs) modulate network activity in the CNS. Thus, functional regulation of alpha7 nAChRs could influence the flow of information through various brain nuclei. It is hypothesized...
8.
Lester R
Bioorg Med Chem Lett
. 2004 Mar;
14(8):1897-900.
PMID: 15050622
Consideration of the activation and desensitization properties of neuronal nicotinic acetylcholine receptors (nAChRs) predicts that there should be a range of concentrations over which low ambient levels of agonist can...
9.
Parker J, Sarkar D, Quick M, Lester R
Br J Pharmacol
. 2003 Mar;
138(5):801-10.
PMID: 12642381
(1) Atropine, a classical muscarinic antagonist, has been reported previously to inhibit neuronal nicotinic acetylcholine receptors (nAChRs). In the present study, the action of atropine has been examined on alpha3beta4...
10.
Quick M, Lester R
J Neurobiol
. 2002 Nov;
53(4):457-78.
PMID: 12436413
The loss of functional response upon continuous or repeated exposure to agonist, desensitization, is an intriguing phenomenon if not as yet a well-defined physiological mechanism. However, detailed evaluation of the...