Roberto Bosotti
Overview
Explore the profile of Roberto Bosotti including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
201
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0
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Recent Articles
1.
Pulvirenti N, Silvetri Y, Clemente F, Bosotti R, Carelli E, Moschetti G, et al.
Eur J Immunol
. 2024 Feb;
54(4):e2350675.
PMID: 38396108
Human CD4EOMES T cells are heterogeneous and contain Th1-cells, Tr1-cells, and CD4CTL. Tr1- cells and non-classical EOMES Th1-cells displayed, respectively, anti- and pro-inflammatory cytokine profiles, but both expressed granzyme-K, produced...
2.
Paroni M, Leccese G, Ranzani V, Moschetti G, Chiara M, Perillo F, et al.
J Crohns Colitis
. 2023 Jul;
17(12):1988-2001.
PMID: 37462681
IFNγ-producing ex-Th17 cells ['Th1/17'] were shown to play a key pathogenic role in experimental colitis and are abundant in the intestine. Here, we identified and characterised a novel, potentially colitogenic...
3.
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs
Crippa S, Conti A, Vavassori V, Ferrari S, Beretta S, Rivis S, et al.
Mol Ther
. 2022 Sep;
30(10):3333.
PMID: 36096132
No abstract available.
4.
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs
Crippa S, Conti A, Vavassori V, Ferrari S, Beretta S, Rivis S, et al.
Mol Ther
. 2022 Aug;
31(1):230-248.
PMID: 35982622
Mesenchymal stromal cells (MSCs) have been employed in vitro to support hematopoietic stem and progenitor cell (HSPC) expansion and in vivo to promote HSPC engraftment. Based on these studies, we...
5.
Bonnal R, Rossetti G, Lugli E, De Simone M, Gruarin P, Brummelman J, et al.
Nat Immunol
. 2021 May;
22(6):735-745.
PMID: 34017124
Regulatory T (T) cells are a barrier for tumor immunity and a target for immunotherapy. Using single-cell transcriptomics, we found that CD4 T cells infiltrating primary and metastatic colorectal cancer...
6.
Crippa S, Santi L, Bosotti R, Porro G, Bernardo M
J Clin Med
. 2019 Dec;
9(1).
PMID: 31861268
Mesenchymal stromal cells (MSCs) are crucial elements in the bone marrow (BM) niche where they provide physical support and secrete soluble factors to control and maintain hematopoietic stem progenitor cells...
7.
Civenni G, Bosotti R, Timpanaro A, Vazquez R, Merulla J, Pandit S, et al.
Cell Metab
. 2019 May;
30(2):303-318.e6.
PMID: 31130467
Cancer stem cells (CSCs) contribute to disease progression and treatment failure in human cancers. The balance among self-renewal, differentiation, and senescence determines the expansion or progressive exhaustion of CSCs. Targeting...
8.
Gruarin P, Maglie S, De Simone M, Haringer B, Vasco C, Ranzani V, et al.
Eur J Immunol
. 2018 Nov;
49(1):96-111.
PMID: 30431161
Whether human IL-10-producing regulatory T cells ("Tr1") represent a distinct differentiation lineage or an unstable activation stage remains a key unsolved issue. Here, we report that Eomesodermin (Eomes) acted as...
9.
Alfen J, Larghi P, Facciotti F, Gagliani N, Bosotti R, Paroni M, et al.
J Allergy Clin Immunol
. 2018 Jan;
142(5):1537-1547.e8.
PMID: 29369775
Background: IL-10 is an anti-inflammatory cytokine required for intestinal immune homeostasis. It mediates suppression of T-cell responses by type 1 regulatory T (T1) cells but is also produced by CD25...