Robert Wessells
Overview
Explore the profile of Robert Wessells including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
359
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Recent Articles
1.
Damschroder D, Zapata-Perez R, Richardson K, Vaz F, Houtkooper R, Wessells R
Dis Model Mech
. 2024 Sep;
17(9).
PMID: 39330214
No abstract available.
2.
Yip C, Wyler S, Liang K, Yamazaki S, Cobb T, Safdar M, et al.
Mol Metab
. 2024 Apr;
84:101939.
PMID: 38621602
Objective: Metamorphosis is a transition from growth to reproduction, through which an animal adopts adult behavior and metabolism. Yet the neural mechanisms underlying the switch are unclear. Here we report...
3.
Richardson K, Sengupta M, Sujkowski A, Libohova K, Harris A, Wessells R, et al.
J Neurosci Res
. 2024 Jan;
102(1):e25278.
PMID: 38284836
Spinal and bulbar muscular atrophy (SBMA) is an X-linked disorder that affects males who inherit the androgen receptor (AR) gene with an abnormal CAG triplet repeat expansion. The resulting protein...
4.
Kagan V, Tyurina Y, Mikulska-Ruminska K, Damschroder D, Vieira Neto E, Lasorsa A, et al.
Nat Metab
. 2023 Nov;
5(12):2184-2205.
PMID: 37996701
Barth syndrome (BTHS) is a life-threatening genetic disorder with unknown pathogenicity caused by mutations in TAFAZZIN (TAZ) that affect remodeling of mitochondrial cardiolipin (CL). TAZ deficiency leads to accumulation of...
5.
Richardson K, Wessells R
PLoS One
. 2023 Sep;
18(9):e0286380.
PMID: 37756350
Barth Syndrome is a rare, X-linked disorder caused by mutation of the gene TAFAZZIN (TAZ). The corresponding Tafazzin protein is involved in the remodeling of cardiolipin, a phospholipid with critical...
6.
Damschroder D, Zapata-Perez R, Richardson K, Vaz F, Houtkooper R, Wessells R
Dis Model Mech
. 2022 Sep;
15(10).
PMID: 36107830
Cardiolipin (CL) is a phospholipid required for proper mitochondrial function. Tafazzin remodels CL to create highly unsaturated fatty acid chains. However, when TAFAZZIN is mutated, CL remodeling is impeded, leading...
7.
Ji J, Damschroder D, Bessert D, Lazcano P, Wessells R, Reynolds C, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2022 Jan;
1867(4):159094.
PMID: 35051613
Cardiolipin (CL) deficiency causes mitochondrial dysfunction and aberrant metabolism that are associated in humans with the severe disease Barth syndrome (BTHS). Several metabolic abnormalities are observed in BTHS patients and...
8.
Sujkowski A, Wessells R
Cells
. 2021 Sep;
10(9).
PMID: 34572128
Chronic exercise is widely recognized as an important contributor to healthspan in humans and in diverse animal models. Recently, we have demonstrated that Sestrins, a family of evolutionarily conserved exercise-inducible...
9.
Damschroder D, Cobb T, Sujkowski A, Wessells R
Bio Protoc
. 2021 Sep;
8(19):e3037.
PMID: 34532514
Exercise induces beneficial systemic adaptations that reduce the incidence of age-related diseases. However, the molecular pathways that elicit these adaptations are not well understood. Understanding the molecular mechanisms that underlie...
10.
Cobb T, Damschroder D, Wessells R
Insect Biochem Mol Biol
. 2021 Feb;
133:103548.
PMID: 33549817
When chill-susceptible insects are exposed to low temperatures they enter a temporary state of paralysis referred to as a chill coma. The most well-studied physiological mechanism of chill coma onset...