Negative Regulators of Angiogenesis: Important Targets for Treatment of Exudative AMD

Overview

Journal Clin Sci (Lond)

Specialties Biochemistry
General Medicine
Science

Date 2017 Jul 7

PMID 28679845

Citations 32

Authors

Mitra Farnoodian

Shoujian Wang

Joel Dietz

Robert W Nickells

Christine M Sorenson

Nader Sheibani

Affiliations

Soon will be listed here.

Abstract

Angiogenesis contributes to the pathogenesis of many diseases including exudative age-related macular degeneration (AMD). It is normally kept in check by a tightly balanced production of pro- and anti-angiogenic factors. The up-regulation of the pro-angiogenic factor, vascular endothelial growth factor (VEGF), is intimately linked to the pathogenesis of exudative AMD, and its antagonism has been effectively targeted for treatment. However, very little is known about potential changes in expression of anti-angiogenic factors and the role they play in choroidal vascular homeostasis and neovascularization associated with AMD. Here, we will discuss the important role of thrombospondins and pigment epithelium-derived factor, two major endogenous inhibitors of angiogenesis, in retinal and choroidal vascular homeostasis and their potential alterations during AMD and choroidal neovascularization (CNV). We will review the cell autonomous function of these proteins in retinal and choroidal vascular cells. We will also discuss the potential targeting of these molecules and use of their mimetic peptides for therapeutic development for exudative AMD.

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