Robert W Egan
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Explore the profile of Robert W Egan including associated specialties, affiliations and a list of published articles.
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20
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532
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Recent Articles
1.
Sharp J, Chea E, Misra S, Orlando R, Popov M, Egan R, et al.
J Am Soc Mass Spectrom
. 2021 Apr;
32(7):1601-1609.
PMID: 33872496
Hydroxyl radical protein footprinting (HRPF) is a powerful and flexible technique for probing changes in protein topography. With the development of the fast photochemical oxidation of proteins (FPOP), it became...
2.
Sharp J, Misra S, Persoff J, Egan R, Weinberger S
Anal Chem
. 2018 Oct;
90(21):12625-12630.
PMID: 30290117
Hydroxyl radical protein footprinting (HRPF) is a powerful method for measuring protein topography, allowing researchers to monitor events that alter the solvent accessible surface of a protein (e.g., ligand binding,...
3.
Celly C, House A, Sehring S, Zhang X, Jones H, Hey J, et al.
Eur J Pharmacol
. 2006 Jun;
540(1-3):147-54.
PMID: 16756974
The Brown-Norway rat is often used to study the allergic pulmonary response. However, relatively little is known about the delayed phase reactions after allergen challenge in this species. To evaluate...
4.
Zhang J, Kuvelkar R, Wu P, Egan R, Billah M, Wang P
Biochem Pharmacol
. 2004 Aug;
68(5):867-73.
PMID: 15294449
Human photoreceptor cGMP-phosphodiesterases (PDE6s) are important reagents in PDE inhibitor discovery. However, recombinant human PDE6s have not been expressed, and isolation of native human PDE6s is highly difficult. In this...
5.
House A, Celly C, Skeans S, Lamca J, Egan R, Hey J, et al.
Eur J Pharmacol
. 2004 Jun;
492(2-3):251-8.
PMID: 15178372
This study investigated the effects of antigen challenge on the cough reflex in dogs that were neonatally sensitized to ragweed. Tidal volume (V(T)), respiratory rate (f), pulmonary resistance (R(L)), dynamic...
6.
Jia Y, Wang X, Varty L, Rizzo C, Yang R, Correll C, et al.
Am J Physiol Lung Cell Mol Physiol
. 2004 Apr;
287(2):L272-8.
PMID: 15075247
Hypotonic stimulation induces airway constriction in normal and asthmatic airways. However, the osmolarity sensor in the airway has not been characterized. TRPV4 (also known as VR-OAC, VRL-2, TRP12, OTRPC4), an...
7.
Wang P, Zhang J, Bian H, Wu P, Kuvelkar R, Kung T, et al.
Biochem J
. 2004 Mar;
380(Pt 2):425-33.
PMID: 14992689
Among the three isoenzymes of neuraminidase (Neu) or sialidase, Neu-1 has been suggested to be induced by cell activation and to be involved in IL (interleukin)-4 biosynthesis in murine T-cells....
8.
Wang P, Wu P, Egan R, Billah M
Gene
. 2003 Oct;
314:15-27.
PMID: 14527714
Previously, four splice variants of human cGMP-specific phosphodiesterase (PDE) 9A (PDEs 9A1, 9A2, 9A3 and 9A4) have been identified. In this study, we have cloned a cDNA representing a new...
9.
Gilchrest H, Cheewatrakoolpong B, Billah M, Egan R, Anthes J, Greenfeder S
Life Sci
. 2003 Sep;
73(20):2571-81.
PMID: 12967681
Mast cells are the central mediating cells of allergic reactions. Binding of allergen specific IgE to high affinity IgE receptor (Fcepsilon RI) and subsequent binding of allergen by the IgE...
10.
McHugh N, Vercesi H, Egan R, Hey J
J Appl Physiol (1985)
. 2003 Apr;
95(2):672-6.
PMID: 12692138
Receptor activator of NF-kappaB ligand (RANKL), produced by osteoblastic lineage cells and activated T cells, is an essential factor for osteoclast differentiation, activation, and survival. Therefore, RANKL is a focal...