Robert W Cho
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Explore the profile of Robert W Cho including associated specialties, affiliations and a list of published articles.
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10
Citations
3765
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Recent Articles
1.
Kanouni T, Severin C, Cho R, Yuen N, Xu J, Shi L, et al.
J Med Chem
. 2020 Oct;
63(23):14522-14529.
PMID: 33034194
Histone demethylase LSDl (KDMlA) belongs to the flavin adenine dinucleotide (FAD) dependent family of monoamine oxidases and is vital in regulation of mammalian biology. Dysregulation and overexpression of LSD1 are...
2.
Nie Z, Shi L, Lai C, Severin C, Xu J, Del Rosario J, et al.
Bioorg Med Chem Lett
. 2018 Nov;
29(1):103-106.
PMID: 30409536
The histone demethylase LSD1 is a key enzyme in the epigenetic regulation of gene transcription. Here we present our efforts to discover small molecule reversible inhibitors of LSD1 as an...
3.
Shimono Y, Zabala M, Cho R, Lobo N, Dalerba P, Qian D, et al.
Cell
. 2009 Aug;
138(3):592-603.
PMID: 19665978
Human breast tumors contain a breast cancer stem cell (BCSC) population with properties reminiscent of normal stem cells. We found 37 microRNAs that were differentially expressed between human BCSCs and...
4.
Diehn M, Cho R, Clarke M
Semin Radiat Oncol
. 2009 Mar;
19(2):78-86.
PMID: 19249645
A growing body of evidence indicates that subpopulations of cancer stem cells (CSCs) drive and maintain many types of human malignancies. These findings have important implications for the development and...
5.
Diehn M, Cho R, Lobo N, Kalisky T, Dorie M, Kulp A, et al.
Nature
. 2009 Feb;
458(7239):780-3.
PMID: 19194462
The metabolism of oxygen, although central to life, produces reactive oxygen species (ROS) that have been implicated in processes as diverse as cancer, cardiovascular disease and ageing. It has recently...
6.
Cho R, Clarke M
Curr Opin Genet Dev
. 2008 Mar;
18(1):48-53.
PMID: 18356041
The theory of cancer stem cells states that a subset of cancer cells within a tumor has the ability to self-renew and differentiate. Only those cells within a tumor that...
7.
Cho R, Wang X, Diehn M, Shedden K, Chen G, Sherlock G, et al.
Stem Cells
. 2007 Nov;
26(2):364-71.
PMID: 17975224
In human breast cancers, a phenotypically distinct minority population of tumorigenic (TG) cancer cells (sometimes referred to as cancer stem cells) drives tumor growth when transplanted into immunodeficient mice. Our...
8.
Dalerba P, Dylla S, Park I, Liu R, Wang X, Cho R, et al.
Proc Natl Acad Sci U S A
. 2007 Jun;
104(24):10158-63.
PMID: 17548814
Recent observations indicate that, in several types of human cancer, only a phenotypic subset of cancer cells within each tumor is capable of initiating tumor growth. This functional subset of...
9.
Dalerba P, Cho R, Clarke M
Annu Rev Med
. 2006 Sep;
58:267-84.
PMID: 17002552
Although monoclonal in origin, most tumors appear to contain a heterogeneous population of cancer cells. This observation is traditionally explained by postulating variations in tumor microenvironment and coexistence of multiple...
10.
Lau J, Trobe J, Ruiz R, Cho R, Wechsler D, Shah G, et al.
J Neuroophthalmol
. 2004 Jun;
24(2):119-24.
PMID: 15179064
A 2-year-old boy with blindness as an isolated symptom was found to have no light perception binocularly because of compression of both optic nerves by a neuroblastoma infiltrating the walls...