Robert Vicha
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Explore the profile of Robert Vicha including associated specialties, affiliations and a list of published articles.
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51
Citations
286
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Recent Articles
1.
Zavodna A, Janovsky P, Kolarik V, Ward J, Pruckova Z, Rouchal M, et al.
Chem Sci
. 2024 Nov;
16(1):83-89.
PMID: 39568923
Rotaxanes can be regarded as storage systems for their wheel components, which broadens their application potential as a complement to the supramolecular systems that retain a mechanically interlocked structure. However,...
2.
Janovsky P, Springer A, Filip J, Pruckova Z, Necas M, Rouchal M, et al.
Chemistry
. 2024 Feb;
30(25):e202400535.
PMID: 38415892
Redox-active components are highly valuable in the construction of molecular devices. We combined two p-phenylenediamines (p-PDA) with a biphenyl (BiPhe) unit to prepare a supramolecular guest 4 consisting of three...
3.
Jelinkova K, Zavodna A, Kaleta J, Janovsky P, Zatloukal F, Necas M, et al.
J Org Chem
. 2023 Oct;
88(22):15615-15625.
PMID: 37882436
Novel binding motifs suitable for the construction of multitopic guest-based molecular devices (e.g., switches, sensors, data storage, and catalysts) are needed in supramolecular chemistry. No rigid, aliphatic binding motif that...
4.
Jurtik M, Greskova B, Pruckova Z, Rouchal M, Dastychova L, Vitkova L, et al.
Carbohydr Polym
. 2023 May;
313:120872.
PMID: 37182963
Hydrogels based on the supramolecular host-guest concept can be prepared if at least one constituent is a polymer chain modified with supramolecular host or guest (or both) units. Low-molecular-weight multitopic...
5.
Rudolfova J, Krystof V, Necas M, Vicha R, Rouchal M
Int J Mol Sci
. 2022 Dec;
23(23).
PMID: 36499470
Purine nucleosides represent an interesting group of nitrogen heterocycles, showing a wide range of biological effects. In this study, we designed and synthesized a series of 6,9-disubstituted and 2,6,9-trisubstituted purine...
6.
Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity
Rouchal M, Rudolfova J, Krystof V, Vojackova V, Cmelik R, Vicha R
Int J Mol Sci
. 2021 Dec;
22(23).
PMID: 34884480
Cyclin-dependent kinases (CDKs) play an important role in the cell-division cycle. Synthetic inhibitors of CDKs are based on 2,6,9-trisubstituted purines and are developed as potential anticancer drugs; however, they have...
7.
Motiei M, de Gouveia L, Sopik T, Vicha R, Skoda D, Cisar J, et al.
Molecules
. 2021 Apr;
26(7).
PMID: 33916814
The alkaline milieu of chronic wounds severely impairs the therapeutic effect of antibiotics, such as rifampicin; as such, the development of new drugs, or the smart delivery of existing drugs,...
8.
Tomecek J, cablova A, Hromadkova A, Novotny J, Marek R, Durnik I, et al.
J Org Chem
. 2021 Mar;
86(6):4483-4496.
PMID: 33648337
Multitopic supramolecular guests with finely tuned affinities toward widely explored cucurbit[]urils (CBs) and cyclodextrins (CDs) have been recently designed and tested as functional components of advanced supramolecular systems. We employed...
9.
Zalesak M, Ruzicka J, Vicha R, Dvorackova M
Chemosphere
. 2020 Nov;
269:128770.
PMID: 33139045
An environmental isolate Comamonas testosteroni RF2 has been previously described to cometabolize trichloroethene (TCE), 1,2-cis-dichloroethene (cDCE), 1,2-trans-dichloroethene (tDCE), and 1,1-dichloroethene (1,1DCE) when grown on phenol and lactate sodium. In this...
10.
Kulkarni S, Jelinkova K, Necas M, Pruckova Z, Rouchal M, Dastychova L, et al.
Chemphyschem
. 2020 Jul;
21(18):2084-2095.
PMID: 32672383
Stilbene derivatives are well-recognised substructures of molecular switches based on photochemically and/or thermally induced (E)/(Z) isomerisation. We combined a stilbene motif with two benzimidazolium arms to prepare new sorts of...