Nanoparticle-Based Rifampicin Delivery System Development

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Apr 30

PMID 33916814

Citations 6

Authors

Marjan Motiei

Luis Pleno de Gouveia

Tomas Sopik

Robert Vicha

David Skoda

Jaroslav Cisar

Reza Khalili

Eva Domincova Bergerova

Lukas Munster

Haojie Fei

Vladimir Sedlarik

Petr Saha

Affiliations

Soon will be listed here.

Abstract

The alkaline milieu of chronic wounds severely impairs the therapeutic effect of antibiotics, such as rifampicin; as such, the development of new drugs, or the smart delivery of existing drugs, is required. Herein, two innovative polyelectrolyte nanoparticles (PENs), composed of an amphiphilic chitosan core and a polycationic shell, were synthesized at alkaline pH, and in vitro performances were assessed by H NMR, elemental analysis, FT-IR, XRD, DSC, DLS, SEM, TEM, UV/Vis spectrophotometry, and HPLC. According to the results, the nanostructures exhibited different morphologies but similar physicochemical properties and release profiles. It was also hypothesized that the simultaneous use of the nanosystem and an antioxidant could be therapeutically beneficial. Therefore, the simultaneous effects of ascorbic acid and PENs were evaluated on the release profile and degradation of rifampicin, in which the results confirmed their synergistic protective effect at pH 8.5, as opposed to pH 7.4. Overall, this study highlighted the benefits of nanoparticulate development in the presence of antioxidants, at alkaline pH, as an efficient approach for decreasing rifampicin degradation.

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References

Mishra P, Pawar R, Bose D, Durgbanshi A, Albiol-Chiva J, Peris-Vicente J . Stability studies of rifampicin in plasma and urine of tuberculosis patients according to the European Medicines Agency Guidelines. Bioanalysis. 2019; 11(8):713-726. DOI: 10.4155/bio-2018-0174. View

Reinbold J, Hierlemann T, Urich L, Uhde A, Muller I, Weindl T . Biodegradable rifampicin-releasing coating of surgical meshes for the prevention of bacterial infections. Drug Des Devel Ther. 2017; 11:2753-2762. PMC: 5609798. DOI: 10.2147/DDDT.S138510. View

Xun M, Huang Z, Xiao Y, Liu Y, Zhang J, Zhang J . Synthesis and Properties of Low-Molecular-Weight PEI-Based Lipopolymers for Delivery of DNA. Polymers (Basel). 2019; 10(10). PMC: 6403936. DOI: 10.3390/polym10101060. View

Arca H, Mosquera-Giraldo L, Pereira J, Sriranganathan N, Taylor L, Edgar K . Rifampin Stability and Solution Concentration Enhancement Through Amorphous Solid Dispersion in Cellulose ω-Carboxyalkanoate Matrices. J Pharm Sci. 2017; 107(1):127-138. DOI: 10.1016/j.xphs.2017.05.036. View

Ali H, Ali M, Wu Y, Selim S, Abdelaal H, Nasr E . Gold Nanorods as Drug Delivery Vehicles for Rifampicin Greatly Improve the Efficacy of Combating Mycobacterium tuberculosis with Good Biocompatibility with the Host Cells. Bioconjug Chem. 2016; 27(10):2486-2492. DOI: 10.1021/acs.bioconjchem.6b00430. View

Righetti M . Crystallization of Polymers Investigated by Temperature-Modulated DSC. Materials (Basel). 2017; 10(4). PMC: 5506965. DOI: 10.3390/ma10040442. View

Motiei M, Sedlarik V, Lucia L, Fei H, Munster L . Stabilization of chitosan-based polyelectrolyte nanoparticle cargo delivery biomaterials by a multiple ionic cross-linking strategy. Carbohydr Polym. 2020; 231:115709. DOI: 10.1016/j.carbpol.2019.115709. View

Lee C, Huang C, Lu P, Ko W, Chen Y, Hsueh P . Role of rifampin for the treatment of bacterial infections other than mycobacteriosis. J Infect. 2017; 75(5):395-408. DOI: 10.1016/j.jinf.2017.08.013. View

Vu H, Nair A, Tran L, Pal S, Senkowsky J, Hu W . A Device to Predict Short-Term Healing Outcome of Chronic Wounds. Adv Wound Care (New Rochelle). 2020; 9(6):312-324. PMC: 7155926. DOI: 10.1089/wound.2019.1064. View

10.

Li H, Huo M, Zhou J, Dai Y, Deng Y, Shi X . Enhanced oral absorption of paclitaxel in N-deoxycholic acid-N, O-hydroxyethyl chitosan micellar system. J Pharm Sci. 2010; 99(11):4543-53. DOI: 10.1002/jps.22159. View

11.

Scolari I, Paez P, Musri M, Petiti J, Torres A, Granero G . Rifampicin loaded in alginate/chitosan nanoparticles as a promising pulmonary carrier against Staphylococcus aureus. Drug Deliv Transl Res. 2020; 10(5):1403-1417. DOI: 10.1007/s13346-019-00705-3. View

12.

Layek B, Singh J . Amino acid grafted chitosan for high performance gene delivery: comparison of amino acid hydrophobicity on vector and polyplex characteristics. Biomacromolecules. 2013; 14(2):485-94. DOI: 10.1021/bm301720g. View

13.

Selvakannan P, Mandal S, Phadtare S, Gole A, Pasricha R, Adyanthaya S . Water-dispersible tryptophan-protected gold nanoparticles prepared by the spontaneous reduction of aqueous chloroaurate ions by the amino acid. J Colloid Interface Sci. 2003; 269(1):97-102. DOI: 10.1016/s0021-9797(03)00616-7. View

14.

Mignani S, Tripathi R, Chen L, Caminade A, Shi X, Majoral J . New Ways to Treat Tuberculosis Using Dendrimers as Nanocarriers. Pharmaceutics. 2018; 10(3). PMC: 6161254. DOI: 10.3390/pharmaceutics10030105. View

15.

Chokshi N, Khatri H, Patel M . Formulation, optimization, and characterization of rifampicin-loaded solid lipid nanoparticles for the treatment of tuberculosis. Drug Dev Ind Pharm. 2018; 44(12):1975-1989. DOI: 10.1080/03639045.2018.1506472. View

16.

Becker C, Dressman J, Junginger H, Kopp S, Midha K, Shah V . Biowaiver monographs for immediate release solid oral dosage forms: rifampicin. J Pharm Sci. 2009; 98(7):2252-67. DOI: 10.1002/jps.21624. View

17.

Tarricone A, Mata K, Chen S, Krishnan P, Landau S, Soave R . Relationship Between pH Shifts and Rate of Healing in Chronic Nonhealing Venous Stasis Lower-Extremity Wounds. J Foot Ankle Surg. 2020; 59(4):748-752. DOI: 10.1053/j.jfas.2020.01.007. View

18.

Vilcheze C, Kim J, Jacobs Jr W . Vitamin C Potentiates the Killing of Mycobacterium tuberculosis by the First-Line Tuberculosis Drugs Isoniazid and Rifampin in Mice. Antimicrob Agents Chemother. 2018; 62(3). PMC: 5826150. DOI: 10.1128/AAC.02165-17. View

19.

Peer D, Karp J, Hong S, Farokhzad O, Margalit R, Langer R . Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol. 2008; 2(12):751-60. DOI: 10.1038/nnano.2007.387. View

20.

Osorio-Madrazo A, David L, Trombotto S, Lucas J, Peniche-Covas C, Domard A . Kinetics study of the solid-state acid hydrolysis of chitosan: evolution of the crystallinity and macromolecular structure. Biomacromolecules. 2010; 11(5):1376-86. DOI: 10.1021/bm1001685. View