Robert Valencia
Overview
Explore the profile of Robert Valencia including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
30
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Recent Articles
1.
Liang W, Nguyen D, Anche G, Valencia R, Periel L, Obinero B, et al.
Cureus
. 2025 Feb;
17(1):e77666.
PMID: 39968427
Sugammadex, a novel agent for reversing neuromuscular blockade, has become the preferred method for reversal over the combination of neostigmine and glycopyrrolate due to its lower risk of adverse effects...
2.
Valencia R, Anche G, Do Rego Barros G, Arostegui V, Sutaria H, McAllister E, et al.
J Osteopath Med
. 2024 Dec;
PMID: 39692236
Context: Medical students report high levels of perceived stress and burnout, especially during the preclinical years. The combination of physical stressors from poor posture, poor sleep quality, and mental stressors...
3.
Darwesh A, Fang L, Altamimi T, Jamieson K, Bassiouni W, Valencia R, et al.
Cardiovasc Res
. 2024 Dec;
PMID: 39658136
Aims: Although current clinical therapies following myocardial infarction have improved patient outcomes, morbidity, and mortality rates secondary to ischemic and ischemia reperfusion (IR) injury remains high. Maintaining mitochondrial quality is...
4.
Valencia R, Kranrod J, Fang L, Soliman A, Azer B, Clemente-Casares X, et al.
FASEB J
. 2024 Jun;
38(13):e23748.
PMID: 38940767
12,13-dihydroxy-9z-octadecenoic acid (12,13-DiHOME) is a linoleic acid diol derived from cytochrome P-450 (CYP) epoxygenase and epoxide hydrolase (EH) metabolism. 12,13-DiHOME is associated with inflammation and mitochondrial damage in the innate...
5.
Kranrod J, Konkel A, Valencia R, Darwesh A, Fischer R, Schunck W, et al.
J Biol Chem
. 2024 May;
300(6):107372.
PMID: 38754781
OMT-28 is a metabolically robust small molecule developed to mimic the structure and function of omega-3 epoxyeicosanoids. However, it remained unknown to what extent OMT-28 also shares the cardioprotective and...
6.
Bassiouni W, Valencia R, Mahmud Z, Seubert J, Schulz R
Basic Res Cardiol
. 2023 Jul;
118(1):29.
PMID: 37495895
During myocardial ischemia and reperfusion (IR) injury matrix metalloproteinase-2 (MMP-2) is rapidly activated in response to oxidative stress. MMP-2 is a multifunctional protease that cleaves both extracellular and intracellular proteins....
7.
Zhabyeyev P, McLean B, Bassiouni W, Valencia R, Paul M, Darwesh A, et al.
J Am Heart Assoc
. 2023 Jun;
12(12):e022352.
PMID: 37318009
Background Identifying new therapeutic targets for preventing the myocardial ischemia-reperfusion injury would have profound implications in cardiovascular medicine. Myocardial ischemia-reperfusion injury remains a major clinical burden in patients with coronary...
8.
Valencia R, Bassiouni W, Darwesh A, Bapuji R, Seubert J
Expert Opin Drug Metab Toxicol
. 2022 Aug;
18(7-8):423-439.
PMID: 35997132
Introduction: Cytochrome P450s (CYPs) are a superfamily of monooxygenases with diverse biological roles. CYP2J2 is an isozyme highly expressed in the heart where it metabolizes endogenous substrates such as N-3/N-6...
9.
Sosnowski D, Jamieson K, Gruzdev A, Li Y, Valencia R, Yousef A, et al.
Am J Physiol Heart Circ Physiol
. 2022 Aug;
323(4):H670-H687.
PMID: 35985007
Endotoxemia elicits a multiorgan inflammatory response that results in cardiac dysfunction and often leads to death. Inflammation-induced metabolism of endogenous N-3 and N-6 polyunsaturated fatty acids generates numerous lipid mediators,...
10.
Miyazaki N, Shiratori R, Oshima T, Zhang Z, Valencia R, Kranrod J, et al.
Biochem Biophys Res Commun
. 2022 Aug;
625:167-173.
PMID: 35963163
Cancer cells rely on glycolysis to generate ATP for survival. However, inhibiting glycolysis is insufficient for the eradication of cancer cells because glycolysis-suppressed cells undergo metabolic reprogramming toward mitochondrial oxidative...