Ahmed M Darwesh
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Explore the profile of Ahmed M Darwesh including associated specialties, affiliations and a list of published articles.
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25
Citations
538
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Recent Articles
1.
Darwesh A, Fang L, Altamimi T, Jamieson K, Bassiouni W, Valencia R, et al.
Cardiovasc Res
. 2024 Dec;
PMID: 39658136
Aims: Although current clinical therapies following myocardial infarction have improved patient outcomes, morbidity, and mortality rates secondary to ischemic and ischemia reperfusion (IR) injury remains high. Maintaining mitochondrial quality is...
2.
Kranrod J, Konkel A, Valencia R, Darwesh A, Fischer R, Schunck W, et al.
J Biol Chem
. 2024 May;
300(6):107372.
PMID: 38754781
OMT-28 is a metabolically robust small molecule developed to mimic the structure and function of omega-3 epoxyeicosanoids. However, it remained unknown to what extent OMT-28 also shares the cardioprotective and...
3.
Kranrod J, Darwesh A, Bassiouni W, Huang A, Fang L, Korodimas J, et al.
J Cardiovasc Pharmacol
. 2024 Jan;
83(1):105-115.
PMID: 38180457
Mounting evidence suggests that cytochrome P450 epoxygenase-derived metabolites of docosahexaenoic acid, called epoxydocosapentaenoic acids (EDPs), limit mitochondrial damage after cardiac injury. In particular, the 19,20-EDP regioisomer has demonstrated potent cardioprotective...
4.
Gopal K, Abdualkader A, Li X, Greenwell A, Karwi Q, Altamimi T, et al.
J Biol Chem
. 2023 Oct;
299(12):105375.
PMID: 37865313
Pyruvate dehydrogenase (PDH) is the rate-limiting enzyme for glucose oxidation that links glycolysis-derived pyruvate with the tricarboxylic acid (TCA) cycle. Although skeletal muscle is a significant site for glucose oxidation...
5.
Zhabyeyev P, McLean B, Bassiouni W, Valencia R, Paul M, Darwesh A, et al.
J Am Heart Assoc
. 2023 Jun;
12(12):e022352.
PMID: 37318009
Background Identifying new therapeutic targets for preventing the myocardial ischemia-reperfusion injury would have profound implications in cardiovascular medicine. Myocardial ischemia-reperfusion injury remains a major clinical burden in patients with coronary...
6.
Valencia R, Bassiouni W, Darwesh A, Bapuji R, Seubert J
Expert Opin Drug Metab Toxicol
. 2022 Aug;
18(7-8):423-439.
PMID: 35997132
Introduction: Cytochrome P450s (CYPs) are a superfamily of monooxygenases with diverse biological roles. CYP2J2 is an isozyme highly expressed in the heart where it metabolizes endogenous substrates such as N-3/N-6...
7.
Sosnowski D, Jamieson K, Darwesh A, Zhang H, Keshavarz-Bahaghighat H, Valencia R, et al.
Front Cardiovasc Med
. 2022 Jun;
9:879209.
PMID: 35665247
Objective: Metabolites derived from -3 and -6 polyunsaturated fatty acids (PUFAs) have both beneficial and detrimental effects on the heart. However, contribution of these lipid mediators to dilated cardiomyopathy (DCM)-associated...
8.
Philippaert K, Kalyaanamoorthy S, Fatehi M, Long W, Soni S, Byrne N, et al.
Circulation
. 2021 Apr;
143(22):2188-2204.
PMID: 33832341
Background: SGLT2 (sodium/glucose cotransporter 2) inhibitors exert robust cardioprotective effects against heart failure in patients with diabetes, and there is intense interest to identify the underlying molecular mechanisms that afford...
9.
Jamieson K, Darwesh A, Sosnowski D, Zhang H, Shah S, Zhabyeyev P, et al.
Int J Mol Sci
. 2021 Feb;
22(4).
PMID: 33567578
Myocardial infarction (MI) accounts for a significant proportion of death and morbidity in aged individuals. The risk for MI in females increases as they enter the peri-menopausal period, generally occurring...
10.
Karwi Q, Wagg C, Altamimi T, Uddin G, Ho K, Darwesh A, et al.
Cardiovasc Diabetol
. 2020 Dec;
19(1):207.
PMID: 33287820
Background: Glucose oxidation is a major contributor to myocardial energy production and its contribution is orchestrated by insulin. While insulin can increase glucose oxidation indirectly by enhancing glucose uptake and...