Robert Vacha
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Explore the profile of Robert Vacha including associated specialties, affiliations and a list of published articles.
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76
Citations
980
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Recent Articles
1.
Role of Divalent Ions in Membrane Models of Polymyxin-Sensitive and Resistant Gram-Negative Bacteria
Savenko M, Vacha R, Ramseyer C, Rivel T
J Chem Inf Model
. 2025 Jan;
65(3):1476-1491.
PMID: 39825802
Polymyxins, critical last-resort antibiotics, impact the distribution of membrane-bound divalent cations in the outer membrane of Gram-negative bacteria. We employed atomistic molecular dynamics simulations to model the effect of displacing...
2.
Rivel T, Biriukov D, Kabelka I, Vacha R
J Chem Inf Model
. 2025 Jan;
65(2):908-920.
PMID: 39792085
Understanding the molecular mechanisms of pore formation is crucial for elucidating fundamental biological processes and developing therapeutic strategies, such as the design of drug delivery systems and antimicrobial agents. Although...
3.
Hazrati M, Sukenik L, Vacha R
J Chem Inf Model
. 2025 Jan;
65(2):845-856.
PMID: 39779296
All-atom molecular dynamics simulations are powerful tools for studying cell membranes and their interactions with proteins and other molecules. However, these processes occur on time scales determined by the diffusion...
4.
Bartos L, Lund M, Vacha R
Soft Matter
. 2024 Dec;
21(2):179-185.
PMID: 39628400
The diffusion of macromolecules, nanoparticles, viruses, and bacteria is essential for targeting hosts or cellular destinations. While these entities can bind to receptors and ligands on host surfaces, the impact...
5.
Linhartova K, Falginella F, Matl M, Sebesta M, Vacha R, Stefl R
Nat Commun
. 2024 Oct;
15(1):9163.
PMID: 39448580
The intrinsically disordered carboxy-terminal domain (CTD) of the largest subunit of RNA Polymerase II (RNAPII) consists of multiple tandem repeats of the consensus heptapeptide Y1-S2-P3-T4-S5-P6-S7. The CTD promotes liquid-liquid phase-separation...
6.
Hazrati M, Vacha R
J Phys Chem B
. 2024 Aug;
128(35):8469-8476.
PMID: 39194157
Despite ongoing research on antimicrobial peptides (AMPs) and cell-penetrating peptides (CPPs), their precise translocation mechanism remains elusive. This includes Buforin 2 (BF2), a well-known AMP, for which spontaneous translocation across...
7.
Deb R, Torres M, Boudny M, Koberska M, Cappiello F, Popper M, et al.
J Med Chem
. 2024 Aug;
67(16):14040-14061.
PMID: 39116273
Peptides that form transmembrane barrel-stave pores are potential alternative therapeutics for bacterial infections and cancer. However, their optimization for clinical translation is hampered by a lack of sequence-function understanding. Recently,...
8.
Biriukov D, Vacha R
ACS Phys Chem Au
. 2024 Jul;
4(4):302-313.
PMID: 39069976
In the last quarter-century, the field of molecular dynamics (MD) has undergone a remarkable transformation, propelled by substantial enhancements in software, hardware, and underlying methodologies. In this Perspective, we contemplate...
9.
Blasco S, Sukenik L, Vacha R
Nanoscale
. 2024 Apr;
16(21):10221-10229.
PMID: 38679949
Membrane fusion is crucial for infection of enveloped viruses, cellular transport, and drug delivery liposomes. Nanoparticles can serve as fusogenic agents facilitating such membrane fusion for direct transmembrane transport. However,...
10.
Bartos L, Drabinova M, Vacha R
Biophys J
. 2024 Apr;
123(10):1240-1252.
PMID: 38615194
Cell membranes act as semi-permeable barriers, often restricting the entry of large or hydrophilic molecules. Nonetheless, certain amphiphilic molecules, such as antimicrobial and cell-penetrating peptides, can cross these barriers. In...