Robert Vacha
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Explore the profile of Robert Vacha including associated specialties, affiliations and a list of published articles.
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76
Citations
980
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Recent Articles
11.
Morton W, Vacha R, Angioletti-Uberti S
J Chem Theory Comput
. 2024 Mar;
20(7):2901-2907.
PMID: 38516954
Coarse grained molecular dynamics simulations have been crucial for investigating the dynamics of nanoparticle uptake by cell membranes via ligand-receptor interactions. These models have enabled researchers to evaluate the effects...
12.
Bartos L, Menon A, Vacha R
Structure
. 2024 Feb;
32(4):505-510.e4.
PMID: 38377988
Scramblases play a pivotal role in facilitating bidirectional lipid transport across cell membranes, thereby influencing lipid metabolism, membrane homeostasis, and cellular signaling. MTCH2, a mitochondrial outer membrane protein insertase, has...
13.
Bartos L, Vacha R
Biophys J
. 2024 Feb;
123(6):693-702.
PMID: 38356262
The transport of molecules across cell membranes is vital for proper cell function and effective drug delivery. While most cell membranes naturally possess an asymmetric lipid composition, research on membrane...
14.
Pajtinka P, Vacha R
J Phys Chem Lett
. 2023 Dec;
15(1):175-179.
PMID: 38153203
Curvature sensing is an essential ability of biomolecules to preferentially localize to membrane regions of a specific curvature. It has been shown that amphipathic helices (AHs), helical peptides with both...
15.
Jahn H, Bartos L, Dearden G, Dittman J, Holthuis J, Vacha R, et al.
Nat Commun
. 2023 Dec;
14(1):8115.
PMID: 38065946
Mitochondria are double-membrane-bounded organelles that depend critically on phospholipids supplied by the endoplasmic reticulum. These lipids must cross the outer membrane to support mitochondrial function, but how they do this...
16.
Bartos L, Menon A, Vacha R
bioRxiv
. 2023 Aug;
PMID: 37645813
Scramblases play a pivotal role in facilitating bidirectional lipid transport across cell membranes, thereby influencing lipid metabolism, membrane homeostasis, and cellular signaling. MTCH2, a mitochondrial outer membrane protein insertase, has...
17.
Semeraro E, Pajtinka P, Marx L, Kabelka I, Leber R, Lohner K, et al.
Biophys J
. 2022 Oct;
121(23):4689-4701.
PMID: 36258677
We previously reported that the synergistically enhanced antimicrobial activity of magainin 2 (MG2a) and PGLa is related to membrane adhesion and fusion. Here, we demonstrate that equimolar mixtures of MG2a...
18.
Falginella F, Kravec M, Drabinova M, Paclikova P, Bryja V, Vacha R
Biochim Biophys Acta Biomembr
. 2022 Jun;
1864(10):183983.
PMID: 35750206
Over the past decades an extensive effort has been made to provide a more comprehensive understanding of Wnt signaling, yet many regulatory and structural aspects remain elusive. Among these, the...
19.
Khirsariya P, Pospisil P, Maier L, Boudny M, Babas M, Kroutil O, et al.
J Med Chem
. 2022 Mar;
65(7):5701-5723.
PMID: 35302777
Histone methyltransferase DOT1L is an attractive therapeutic target for the treatment of hematological malignancies. Here, we report the design, synthesis, and profiling of new DOT1L inhibitors based on nonroutine carbocyclic...
20.
Kabelka I, Georgiev V, Marx L, Pajtinka P, Lohner K, Pabst G, et al.
Biophys J
. 2022 Feb;
121(5):852-861.
PMID: 35134334
We previously speculated that the synergistically enhanced antimicrobial activity of Magainin 2 and PGLa is related to membrane adhesion, fusion, and further membrane remodeling. Here we combined computer simulations with...