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Robert V Martinez

Explore the profile of Robert V Martinez including associated specialties, affiliations and a list of published articles. Areas
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Articles 19
Citations 492
Followers 0
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Recent Articles
1.
Wang J, Casimiro-Garcia A, Johnson B, Duffen J, Cain M, Savary L, et al.
Sci Rep . 2023 Oct; 13(1):16919. PMID: 37805649
Type 2 diabetes (T2D) and its complications can have debilitating, sometimes fatal consequences for afflicted individuals. The disease can be difficult to control, and therapeutic strategies to prevent T2D-induced tissue...
2.
Ross T, Crowley C, Kelly K, Rinaldi A, Beebe D, Lech M, et al.
Cell Mol Gastroenterol Hepatol . 2020 Jun; 10(4):829-851. PMID: 32526482
Background & Aims: Disordered metabolism, steatosis, hepatic inflammation, and fibrosis contribute to the pathogenesis of nonalcoholic steatohepatitis (NASH). Acetyl-CoA carboxylase (ACC) catalyzes the first committed step in de novo lipogenesis...
3.
Zhang X, MacDonald B, Gao H, Shamashkin M, Coyle A, Martinez R, et al.
J Biol Chem . 2020 Feb; 295(5):1367. PMID: 32005644
No abstract available.
4.
Min-DeBartolo J, Schlerman F, Akare S, Wang J, McMahon J, Zhan Y, et al.
PLoS One . 2020 Jan; 14(12):e0226854. PMID: 31891606
Non-alcoholic fatty liver disease (NAFLD) is a progressive liver disease characterized by dysregulated lipid metabolism and chronic inflammation ultimately resulting in fibrosis. Untreated, NAFLD may progress to non-alcoholic steatohepatitis (NASH),...
5.
Zhang C, Dower K, Zhang B, Martinez R, Lin L, Zhao S
Sci Rep . 2018 May; 8(1):7624. PMID: 29769602
Obese ZSF1 rats exhibit spontaneous time-dependent diabetic nephropathy and are considered to be a highly relevant animal model of progressive human diabetic kidney disease. We previously identified gene expression changes...
6.
Dower K, Zhao S, Schlerman F, Savary L, Campanholle G, Johnson B, et al.
PLoS One . 2017 Jul; 12(7):e0181861. PMID: 28746409
ZSF1 rats exhibit spontaneous nephropathy secondary to obesity, hypertension, and diabetes, and have gained interest as a model system with potentially high translational value to progressive human disease. To thoroughly...
7.
Zhang X, MacDonald B, Gao H, Shamashkin M, Coyle A, Martinez R, et al.
J Biol Chem . 2015 Dec; 291(5):2435-43. PMID: 26631728
The Wnt family of secreted glycolipoproteins plays pivotal roles in development and human diseases. Tiki family proteins were identified as novel Wnt inhibitors that act by cleaving the Wnt amino-terminal...
8.
Sharma A, Huard C, Vernochet C, Ziemek D, Knowlton K, Tyminski E, et al.
PLoS One . 2014 Mar; 9(3):e92608. PMID: 24658703
Brown adipose tissue (BAT) plays a pivotal role in promoting energy expenditure by the virtue of uncoupling protein-1 (UCP-1) that differentiates BAT from its energy storing white adipose tissue (WAT)...
9.
Tremblay F, Huard C, Dow J, Gareski T, Will S, Richard A, et al.
Endocrinology . 2012 Jul; 153(9):4290-303. PMID: 22753645
Coiled-coil domain containing 80 (Ccdc80) is a secreted protein highly enriched in mouse and human white adipose tissue (WAT) that plays an important role during adipocyte differentiation in vitro. To...
10.
Auld K, Berasi S, Liu Y, Cain M, Zhang Y, Huard C, et al.
J Mol Endocrinol . 2012 Feb; 48(2):177-91. PMID: 22333182
Based on its homology to the estrogen receptor and its roles in osteoblast and chondrocyte differentiation, the orphan nuclear receptor estrogen-related receptor α (ERRα (ESRRA)) is an intriguing therapeutic target...