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Giovanna Ferrari-Amorotti

Explore the profile of Giovanna Ferrari-Amorotti including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 17
Citations 373
Followers 0
Related Specialties
Oncology
Biochemistry
Cell Biology
Top 10 Co-Authors
Bruno Calabretta
Sara Cattelani
Angela Rachele Soliera
Clara Guerzoni
Gloria Manzotti
Giuseppe Raschella
Valentina Fragliasso
Ying Zhang
Carlo Dominici
Francesca Corradini
Published In
Blood
J Biol Chem
Neoplasia
Cell Cycle
Cancer Res
Affiliations
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Recent Articles
1.
Monocyte-macrophage differentiation of acute myeloid leukemia cell lines by small molecules identified through interrogation of the Connectivity Map database
Manzotti G, Parenti S, Ferrari-Amorotti G, Soliera A, Cattelani S, Montanari M, et al.
Cell Cycle . 2015 Jun; 14(16):2578-89. PMID: 26102293
The transcription factor C/EBPα is required for granulocytic differentiation of normal myeloid progenitors and is frequently inactivated in acute myeloid leukemia (AML) cells. Ectopic expression of C/EBPα in AML cells...
2.
Suppression of invasion and metastasis of triple-negative breast cancer lines by pharmacological or genetic inhibition of slug activity
Ferrari-Amorotti G, Chiodoni C, Shen F, Cattelani S, Soliera A, Manzotti G, et al.
Neoplasia . 2014 Dec; 16(12):1047-58. PMID: 25499218
Most triple-negative breast cancers (TNBCs) exhibit gene expression patterns associated with epithelial-to-mesenchymal transition (EMT), a feature that correlates with a propensity for metastatic spread. Overexpression of the EMT regulator Slug...
3.
Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion
Ferrari-Amorotti G, Fragliasso V, Esteki R, Prudente Z, Soliera A, Cattelani S, et al.
Cancer Res . 2012 Oct; 73(1):235-45. PMID: 23054398
The process of epithelial-mesenchymal transition (EMT) which is required for cancer cell invasion is regulated by a family of E-box-binding transcription repressors, which include Snail (SNAIL1) and Slug (SNAI2). Snail...
4.
The p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53-72P isoform
Cattelani S, Ferrari-Amorotti G, Galavotti S, Defferrari R, Tanno B, Cialfi S, et al.
Neoplasia . 2012 Aug; 14(7):634-43. PMID: 22904680
The p53 gene is rarely mutated in neuroblastoma, but codon 72 polymorphism that modulates its proapoptotic activity might influence cancer risk and clinical outcome. We investigated whether this polymorphism affects...
5.
Phosphorylation of serine 21 modulates the proliferation inhibitory more than the differentiation inducing effects of C/EBPα in K562 cells
Fragliasso V, Chiodo Y, Ferrari-Amorotti G, Soliera A, Manzotti G, Cattelani S, et al.
J Cell Biochem . 2012 Jan; 113(5):1704-13. PMID: 22212957
The CCAAT/enhancer binding protein α (C/EBPα) is a transcription factor required for differentiation of myeloid progenitors. In acute myeloid leukemia (AML) cells expressing the constitutively active FLT3-ITD receptor tyrosine kinase,...
6.
Regulation of microRNA-145 by growth arrest and differentiation
La Rocca G, Shi B, Audia A, Ferrari-Amorotti G, Mellert H, Calabretta B, et al.
Exp Cell Res . 2010 Nov; 317(4):488-95. PMID: 21111732
MicroRNA145 (miR145), a tumor suppressor miR, has been reported to inhibit growth of human cancer cells, to induce differentiation and to cause apoptosis, all conditions that result in growth arrest....
7.
Expression of the transcriptional repressor Gfi-1 is regulated by C/EBP{alpha} and is involved in its proliferation and colony formation-inhibitory effects in p210BCR/ABL-expressing cells
Lidonnici M, Audia A, Soliera A, Prisco M, Ferrari-Amorotti G, Waldron T, et al.
Cancer Res . 2010 Oct; 70(20):7949-59. PMID: 20924107
Ectopic expression of CAAT/enhancer binding protein α (C/EBPα) in p210BCR/ABL-expressing cells induces granulocytic differentiation, inhibits proliferation, and suppresses leukemogenesis. To dissect the molecular mechanisms underlying these biological effects, C/EBPα-regulated genes...
8.
The biological effects of C/EBPalpha in K562 cells depend on the potency of the N-terminal regulatory region, not on specificity of the DNA binding domain
Ferrari-Amorotti G, Mariani S, Novi C, Cattelani S, Pecorari L, Corradini F, et al.
J Biol Chem . 2010 Jul; 285(40):30837-50. PMID: 20659895
The transcription factor C/EBPα is more potent than C/EBPβ in inducing granulocitic differentiation and inhibiting BCR/ABL-expressing cells. We took a "domain swapping" approach to assess biological effects, modulation of gene...
9.
Expression of Slug is regulated by c-Myb and is required for invasion and bone marrow homing of cancer cells of different origin
Tanno B, Sesti F, Cesi V, Bossi G, Ferrari-Amorotti G, Bussolari R, et al.
J Biol Chem . 2010 Jul; 285(38):29434-45. PMID: 20622260
In metastatic cancer cells, the process of invasion is regulated by several transcription factors that induce changes required for migration and resistance to apoptosis. Slug (SNAI2, Snail2) is involved in...
10.
Elongation Factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility
Pecorari L, Marin O, Silvestri C, Candini O, Rossi E, Guerzoni C, et al.
Mol Cancer . 2009 Aug; 8:58. PMID: 19646290
Background: Akt/PKB is a serine/threonine kinase that has attracted much attention because of its central role in regulating cell proliferation, survival, motility and angiogenesis. Activation of Akt in breast cancer...