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Robert V Bruggner

Explore the profile of Robert V Bruggner including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 3412
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Recent Articles
1.
Aghaeepour N, Simonds E, Knapp D, Bruggner R, Sachs K, Culos A, et al.
Bioinformatics . 2018 Jun; 34(23):4131-4133. PMID: 29850785
Motivation: High-parameter single-cell technologies can reveal novel cell populations of interest, but studying or validating these populations using lower-parameter methods remains challenging. Results: Here, we present GateFinder, an algorithm that...
2.
Gaudilliere B, Fragiadakis G, Bruggner R, Nicolau M, Finck R, Tingle M, et al.
Sci Transl Med . 2014 Sep; 6(255):255ra131. PMID: 25253674
Delayed recovery from surgery causes personal suffering and substantial societal and economic costs. Whether immune mechanisms determine recovery after surgical trauma remains ill-defined. Single-cell mass cytometry was applied to serial...
3.
Bruggner R, Bodenmiller B, Dill D, Tibshirani R, Nolan G
Proc Natl Acad Sci U S A . 2014 Jul; 111(26):E2770-7. PMID: 24979804
Elucidation and examination of cellular subpopulations that display condition-specific behavior can play a critical contributory role in understanding disease mechanism, as well as provide a focal point for development of...
4.
Bodenmiller B, Zunder E, Finck R, Chen T, Savig E, Bruggner R, et al.
Nat Biotechnol . 2012 Aug; 30(9):858-67. PMID: 22902532
Mass cytometry facilitates high-dimensional, quantitative analysis of the effects of bioactive molecules on human samples at single-cell resolution, but instruments process only one sample at a time. Here we describe...
5.
Linderman M, Bjornson Z, Simonds E, Qiu P, Bruggner R, Sheode K, et al.
Bioinformatics . 2012 Jul; 28(18):2400-1. PMID: 22782546
Motivation: Recent advances in flow cytometry enable simultaneous single-cell measurement of 30+ surface and intracellular proteins. CytoSPADE is a high-performance implementation of an interface for the Spanning-tree Progression Analysis of...
6.
Qiu P, Simonds E, Bendall S, Gibbs Jr K, Bruggner R, Linderman M, et al.
Nat Biotechnol . 2011 Oct; 29(10):886-91. PMID: 21964415
The ability to analyze multiple single-cell parameters is critical for understanding cellular heterogeneity. Despite recent advances in measurement technology, methods for analyzing high-dimensional single-cell data are often subjective, labor intensive...
7.
Bendall S, Simonds E, Qiu P, Amir E, Krutzik P, Finck R, et al.
Science . 2011 May; 332(6030):687-96. PMID: 21551058
Flow cytometry is an essential tool for dissecting the functional complexity of hematopoiesis. We used single-cell "mass cytometry" to examine healthy human bone marrow, measuring 34 parameters simultaneously in single...
8.
Kirkness E, Haas B, Sun W, Braig H, Perotti M, Clark J, et al.
Proc Natl Acad Sci U S A . 2010 Jun; 107(27):12168-73. PMID: 20566863
As an obligatory parasite of humans, the body louse (Pediculus humanus humanus) is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. Here, we present...
9.
Lawson D, Arensburger P, Atkinson P, Besansky N, Bruggner R, Butler R, et al.
Nucleic Acids Res . 2008 Nov; 37(Database issue):D583-7. PMID: 19028744
VectorBase (http://www.vectorbase.org) is an NIAID-funded Bioinformatic Resource Center focused on invertebrate vectors of human pathogens. VectorBase annotates and curates vector genomes providing a web accessible integrated resource for the research...
10.
Nene V, Wortman J, Lawson D, Haas B, Kodira C, Tu Z, et al.
Science . 2007 May; 316(5832):1718-23. PMID: 17510324
We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5...