Robert U Simpson
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Explore the profile of Robert U Simpson including associated specialties, affiliations and a list of published articles.
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19
Citations
665
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Recent Articles
1.
Dorsch M, Nemerovski C, Ellingrod V, Cowger J, Dyke D, Koelling T, et al.
J Cardiovasc Pharmacol Ther
. 2014 Feb;
19(5):439-45.
PMID: 24500905
Introduction: Vitamin D deficiency has been associated with the development of myocardial hypertrophy and inflammation. These findings suggest that vitamin D status and vitamin D receptor (VDR) genomics may play...
2.
Kim S, Chen G, King A, Jeon C, Christensen P, Zhao L, et al.
Lung Cancer
. 2012 May;
77(2):265-71.
PMID: 22564539
Purpose: The anti-proliferative effects of 1α,25-dihydroxyvitamin D(3) (1,25-D(3), calcitriol, the active form of vitamin D) are mediated by the nuclear vitamin D receptor (VDR). In the present study, we characterized...
3.
Johnson L, Sauder K, Rodansky E, Simpson R, Higgins P
Exp Mol Pathol
. 2012 May;
93(1):91-8.
PMID: 22542712
Intestinal fibrosis is one of the major complications of Crohn's disease (CD) for which there are no effective pharmacological therapies. Vitamin D deficiency is common in CD, though it is...
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5.
Chen G, Kim S, King A, Zhao L, Simpson R, Christensen P, et al.
Clin Cancer Res
. 2010 Dec;
17(4):817-26.
PMID: 21169243
Purpose: The active form of vitamin D, 1α,25-dihydroxyvitamin D(3) (1,25-D(3)), exerts antiproliferative effects in cancers, including lung adenocarcinoma (AC). CYP24A1 is overexpressed in many cancers and encodes the enzyme that...
6.
Zhao G, Simpson R
J Steroid Biochem Mol Biol
. 2010 Mar;
121(1-2):159-63.
PMID: 20304057
We show that 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) and a synthetic non-genotropic vitamin D analog agonist, 1a,25(OH)2-lumisterol (JN), exhibit similar rapid effects on sarcomere shortening (contraction) of isolated adult cardiomyocyte. We also...
7.
King A, Beer D, Christensen P, Simpson R, Ramnath N
Anticancer Agents Med Chem
. 2010 Feb;
10(3):213-24.
PMID: 20184548
There is increasing evidence linking the incidence of certain cancers to low serum Vitamin D levels. The active metabolite of Vitamin D, calcitriol (1, 25-Dihydroxyvitamin D(3), 1,25(OH)(2)D(3)) apart from a...
8.
Scragg R, Camargo Jr C, Simpson R
Am J Cardiol
. 2010 Jan;
105(1):122-8.
PMID: 20102903
Vitamin D may protect against cardiovascular disease, but its association with cardiac function is unclear. The aim of this study was to examine the associations of serum 25-hydroxyvitamin D (25[OH]D)...
9.
Zhao G, Simpson R
Steroids
. 2009 Dec;
75(8-9):555-9.
PMID: 20015453
The active form of vitamin D, 1alpha, 25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), mediates both genomic and rapid non-genomic actions in heart cells. We have previously shown that the vitamin D receptor (VDR)...
10.
Wilke R, Simpson R, Mukesh B, Bhupathi S, Dart R, Ghebranious N, et al.
Pharmacogenomics
. 2009 Nov;
10(11):1789-97.
PMID: 19891555
Aims: We tested the hypothesis that genetic variation in vitamin D-dependent signaling is associated with congestive heart failure in human subjects with hypertension. Materials & Methods: Functional polymorphisms were selected...