Robert T Dirksen
Overview
Explore the profile of Robert T Dirksen including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
149
Citations
5085
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Liang C, Malik S, He M, Groom L, Ture S, OConnor T, et al.
FASEB J
. 2024 Oct;
38(20):e70120.
PMID: 39466056
Pathogenic variants in the type I ryanodine receptor (RYR1) result in a wide range of muscle disorders referred to as RYR1-related myopathies (RYR1-RM). We developed the first RYR1-RM mouse model...
2.
Zhao N, Michelucci A, Pietrangelo L, Malik S, Groom L, Leigh J, et al.
EMBO J
. 2024 Oct;
43(23):5941-5971.
PMID: 39420094
Tubular aggregate myopathy (TAM) is a heritable myopathy primarily characterized by progressive muscle weakness, elevated levels of creatine kinase (CK), hypocalcemia, exercise intolerance, and the presence of tubular aggregates (TAs)....
3.
Peng W, Chung K, Lawrence B, OBanion M, Dirksen R, Wojtovich A, et al.
Free Radic Biol Med
. 2024 Sep;
224:785-796.
PMID: 39317269
Iron is critical for neuronal activity and metabolism, and iron dysregulation alters these functions in age-related neurodegenerative disorders, such as Alzheimer's disease (AD). AD is a chronic neurodegenerative disease characterized...
4.
Di Fonso A, Serano M, He M, Leigh J, Rastelli G, Dirksen R, et al.
Biomedicines
. 2024 Aug;
12(8).
PMID: 39200116
Store-operated Ca entry (SOCE) is a ubiquitous cellular mechanism that cells use to activate extracellular Ca entry when intracellular Ca stores are depleted. In skeletal muscle, SOCE occurs within Ca...
5.
van de Camp S, Stinissen L, Huseth A, Simon B, Ryan J, Sarkozy A, et al.
J Neuromuscul Dis
. 2024 Aug;
11(5):1067-1083.
PMID: 39150833
Background And Objective: Pathogenic variants of RYR1, the gene encoding the principal sarcoplasmic reticulum calcium release channel (RyR1) with a crucial role in excitation-contraction coupling, are among the most common...
6.
Peng W, Chung K, Lawrence B, OBanion M, Dirksen R, Wojtovich A, et al.
bioRxiv
. 2024 Aug;
PMID: 39149382
Iron is critical for neuronal activity and metabolism, and iron dysregulation alters these functions in age-related neurodegenerative disorders, such as Alzheimer's disease (AD). AD is a chronic neurodegenerative disease characterized...
7.
Asantewaa G, Tuttle E, Ward N, Kang Y, Kim Y, Kavanagh M, et al.
Nat Commun
. 2024 Jul;
15(1):6152.
PMID: 39034312
Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is...
8.
Strohm A, OConnor T, Oldfield S, Young S, Hammond C, McCall M, et al.
J Appl Physiol (1985)
. 2023 Nov;
136(1):89-108.
PMID: 37969082
We present the first demonstration of chronic in vivo imaging of microglia in mice undergoing voluntary wheel running. We find that healthy mice undergoing voluntary wheel running have similar microglia...
9.
Endo Y, Groom L, Wang S, Pannia E, Griffiths N, Van Gennip J, et al.
Hum Mol Genet
. 2023 Nov;
33(3):254-269.
PMID: 37930228
CACNA1S-related myopathy, due to pathogenic variants in the CACNA1S gene, is a recently described congenital muscle disease. Disease associated variants result in loss of gene expression and/or reduction of Cav1.1...
10.
OConnor T, Zhao N, Orciuoli H, Brasile A, Pietrangelo L, He M, et al.
bioRxiv
. 2023 Oct;
PMID: 37808709
Tubular aggregate myopathy (TAM) is an inherited skeletal muscle disease associated with progressive muscle weakness, cramps, and myalgia. Tubular aggregates (TAs) are regular arrays of highly ordered and densely packed...