Robert P Sparks
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Explore the profile of Robert P Sparks including associated specialties, affiliations and a list of published articles.
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16
Citations
92
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Recent Articles
1.
Li W, Sparks R, Sun C, Yang Y, Pantano L, Kirchner R, et al.
Nat Commun
. 2025 Mar;
16(1):2109.
PMID: 40025044
Hepatic stellate cells (HSCs) are activated with chronic liver injury and transdifferentiate into myofibroblasts, which produce excessive extracellular matrices that form the fibrotic scar. While the progression of fibrosis is...
2.
Sun C, Zhou C, Daneshvar K, Ben Saad A, Kratkiewicz A, Toles B, et al.
Hepatology
. 2024 Apr;
81(3):853-869.
PMID: 38563629
Background And Aims: Fibrosis is the common end point for all forms of chronic liver injury, and the progression of fibrosis leads to the development of end-stage liver disease. Activation...
3.
Lui A, Patel R, Krause-Hauch M, Sparks R, Patel N
Int J Mol Sci
. 2023 Sep;
24(18).
PMID: 37762628
Type 2 diabetes mellitus is a chronic metabolic disease with no cure. Adipose tissue is a major site of systemic insulin resistance. Sortilin is a central component of the glucose...
4.
Patel R, Lui A, Hudson C, Moss L, Sparks R, Hill S, et al.
Sci Rep
. 2023 Jan;
13(1):317.
PMID: 36609440
Shifts in normal aging set stage for neurodegeneration and dementia affecting 1 in 10 adults. The study demonstrates that lncRNA GAS5 is decreased in aged and Alzheimer's disease brain. The...
5.
Sparks R, Arango A, Starr M, Aboff Z, Hurst L, Rivera-Kohr D, et al.
J Biol Chem
. 2022 Oct;
298(11):102576.
PMID: 36257250
No abstract available.
6.
Patel A, Dobbins T, Kong X, Patel R, Carter G, Harding L, et al.
J Cell Mol Med
. 2022 Jul;
26(15):4183-4194.
PMID: 35801494
Excessive dietary intake of fat results in its storage in white adipose tissue (WAT). Energy expenditure through lipid oxidation occurs in brown adipose tissue (BAT). Certain WAT depots can undergo...
7.
Li W, Chen J, Sun C, Sparks R, Pantano L, Rahman R, et al.
Elife
. 2022 May;
11.
PMID: 35617485
Chronic liver injury causes fibrosis, characterized by the formation of scar tissue resulting from excessive accumulation of extracellular matrix (ECM) proteins. Hepatic stellate cell (HSC) myofibroblasts are the primary cell...
8.
Sparks R, Lawless W, Arango A, Tajkhorshid E, Fratti R
J Vis Exp
. 2022 Feb;
(180).
PMID: 35225279
The ability to determine the binding affinity of lipids to proteins is an essential part of understanding protein-lipid interactions in membrane trafficking, signal transduction and cytoskeletal remodeling. Classic tools for...
9.
Sparks R, Arango A, Jenkins J, Guida W, Tajkhorshid E, Sparks C, et al.
Biochemistry
. 2020 Nov;
59(45):4321-4335.
PMID: 33153264
ApoB lipoproteins (apo B-Lp) are produced in hepatocytes, and their secretion requires the cargo receptor sortilin. We examined the secretion of apo B-Lp-containing very low-density lipoprotein (VLDL), an LDL progenitor....
10.
Sparks R, Arango A, Starr M, Aboff Z, Hurst L, Rivera-Kohr D, et al.
J Biol Chem
. 2019 Sep;
294(46):17168-17185.
PMID: 31515268
The homeostasis of most organelles requires membrane fusion mediated by oluble -ethylmaleimide-sensitive factor (NSF) ttachment protein ceptors (SNAREs). SNAREs undergo cycles of activation and deactivation as membranes move through the...