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Robert P Sheehan

Explore the profile of Robert P Sheehan including associated specialties, affiliations and a list of published articles. Areas
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Articles 4
Citations 180
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Recent Articles
1.
Wang H, Sheehan R, Palmer A, Everley R, Boswell S, Ron-Harel N, et al.
Cell Syst . 2019 May; 8(5):412-426.e7. PMID: 31078528
Tyrosine kinase inhibitors (TKIs) are widely used to treat solid tumors but can be cardiotoxic. The molecular basis for this toxicity and its relationship to therapeutic mechanisms remain unclear; we...
2.
Harris L, Hogg J, Tapia J, Sekar J, Gupta S, Korsunsky I, et al.
Bioinformatics . 2016 Jul; 32(21):3366-3368. PMID: 27402907
Availability And Implementation: Stable BioNetGen releases (Linux, Mac OS/X and Windows), with documentation, are available at http://bionetgen.org Source code is available at http://github.com/RuleWorld/bionetgen CONTACT: bionetgen.help@gmail.comSupplementary information: Supplementary data are available...
3.
Malkin A, Sheehan R, Mathew S, Federspiel W, Redl H, Clermont G
PLoS Comput Biol . 2015 Oct; 11(10):e1004314. PMID: 26468651
Neutrophils play a central role in eliminating bacterial pathogens, but may also contribute to end-organ damage in sepsis. Interleukin-8 (IL-8), a key modulator of neutrophil function, signals through neutrophil specific...
4.
Hawse W, Sheehan R, Miskov-Zivanov N, Menk A, Kane L, Faeder J, et al.
J Immunol . 2015 Apr; 194(10):4615-9. PMID: 25855357
Signaling via the Akt/mammalian target of rapamycin pathway influences CD4(+) T cell differentiation; low levels favor regulatory T cell induction and high levels favor Th induction. Although the lipid phosphatase...