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Robert P Machold

Explore the profile of Robert P Machold including associated specialties, affiliations and a list of published articles. Areas
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Articles 14
Citations 840
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Recent Articles
1.
Miyoshi G, Ueta Y, Yagasaki Y, Kishi Y, Fishell G, Machold R, et al.
Proc Natl Acad Sci U S A . 2024 Apr; 121(16):e2317783121. PMID: 38588430
GABAergic inhibitory interneurons, originating from the embryonic ventral forebrain territories, traverse a convoluted migratory path to reach the neocortex. These interneuron precursors undergo sequential phases of tangential and radial migration...
2.
Miyoshi G, Ueta Y, Natsubori A, Hiraga K, Osaki H, Yagasaki Y, et al.
Nat Commun . 2021 Jun; 12(1):3773. PMID: 34145239
Abnormalities in GABAergic inhibitory circuits have been implicated in the aetiology of autism spectrum disorder (ASD). ASD is caused by genetic and environmental factors. Several genes have been associated with...
3.
Schuman B, Machold R, Hashikawa Y, Fuzik J, Fishell G, Rudy B
J Neurosci . 2018 Nov; 39(1):125-139. PMID: 30413647
Sensory perception depends on neocortical computations that contextually adjust sensory signals in different internal and environmental contexts. Neocortical layer 1 (L1) is the main target of cortical and subcortical inputs...
4.
Li Q, Kellner D, Hatch H, Yumita T, Sanchez S, Machold R, et al.
PLoS Genet . 2017 May; 13(5):e1006815. PMID: 28558011
Sleep is an ancient animal behavior that is regulated similarly in species ranging from flies to humans. Various genes that regulate sleep have been identified in invertebrates, but whether the...
5.
Stouffer M, Woods C, Patel J, Lee C, Witkovsky P, Bao L, et al.
Nat Commun . 2015 Oct; 6:8543. PMID: 26503322
Insulin activates insulin receptors (InsRs) in the hypothalamus to signal satiety after a meal. However, the rising incidence of obesity, which results in chronically elevated insulin levels, implies that insulin...
6.
Miyoshi G, Young A, Petros T, Karayannis T, McKenzie Chang M, Lavado A, et al.
J Neurosci . 2015 Sep; 35(37):12869-89. PMID: 26377473
Significance Statement: Despite the recognition that 30% of GABAergic cortical interneurons originate from the caudal ganglionic eminence (CGE), to date, a specific transcriptional program that selectively regulates the development of...
7.
Machold R
Behav Brain Res . 2013 Jul; 256:51-5. PMID: 23810416
The parabigeminal (PBG), pedunculopontine (PPTg), and laterodorsal tegmental (LDTg) nuclei located in the rostral brainstem are the primary sources of the neurotransmitter acetylcholine (ACh) for the midbrain and thalamus, and...
8.
Lee C, Machold R, Witkovsky P, Rice M
J Neurosci . 2013 Jan; 33(3):1157-68. PMID: 23325252
Substantia nigra pars reticulata (SNr) GABAergic neurons are projection neurons that convey output from the basal ganglia to target structures. These neurons exhibit spontaneous regular firing, but also exhibit burst...
9.
Patel J, Rossignol E, Rice M, Machold R
Nat Commun . 2012 Nov; 3:1172. PMID: 23132022
Dopamine transmission is critical for exploratory motor behaviour. A key regulator is acetylcholine; forebrain acetylcholine regulates striatal dopamine release, whereas brainstem cholinergic inputs regulate the transition of dopamine neurons from...
10.
Carney R, Mangin J, Hayes L, Mansfield K, Sousa V, Fishell G, et al.
Neural Dev . 2010 May; 5:14. PMID: 20507551
Background: The mammalian amygdala is composed of two primary functional subdivisions, classified according to whether the major output projection of each nucleus is excitatory or inhibitory. The posterior dorsal and...