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Goichi Miyoshi

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Articles 26
Citations 2959
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Asano H, Arai M, Narita A, Kuroiwa T, Fukuchi M, Yoshimoto Y, et al.
Front Cell Neurosci . 2025 Jan; 18:1513347. PMID: 39882215
Autism spectrum disorder (ASD) is characterized by social deficits and restricted behaviors, with developmental defects in GABAergic circuits proposed as a key underlying etiology. Here, we introduce the V-Y assay,...
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Narita A, Asano H, Kudo H, Miyata S, Shutoh F, Miyoshi G
Neurosci Res . 2024 Aug; 209:18-27. PMID: 39134225
Environmental factors have well-documented impacts on brain development and mental health. Therefore, it is crucial to employ a reliable assay system to assess the spatial preference of model animals. In...
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Miyoshi G, Ueta Y, Yagasaki Y, Kishi Y, Fishell G, Machold R, et al.
Proc Natl Acad Sci U S A . 2024 Apr; 121(16):e2317783121. PMID: 38588430
GABAergic inhibitory interneurons, originating from the embryonic ventral forebrain territories, traverse a convoluted migratory path to reach the neocortex. These interneuron precursors undergo sequential phases of tangential and radial migration...
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Takahashi M, Nakabayashi T, Mita N, Jin X, Aikawa Y, Sasamoto K, et al.
Mol Brain . 2022 Apr; 15(1):37. PMID: 35484559
Cyclin-dependent kinase 5 (Cdk5) /p35 is involved in many developmental processes of the central nervous system. Cdk5/p35 is also implicated in synaptic plasticity, learning and memory. Several lines of conditional...
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Miyoshi G, Ueta Y, Natsubori A, Hiraga K, Osaki H, Yagasaki Y, et al.
Nat Commun . 2021 Jun; 12(1):3773. PMID: 34145239
Abnormalities in GABAergic inhibitory circuits have been implicated in the aetiology of autism spectrum disorder (ASD). ASD is caused by genetic and environmental factors. Several genes have been associated with...
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Hou P, Miyoshi G, Hanashima C
Nat Commun . 2019 Aug; 10(1):3581. PMID: 31395862
The bimodal requisite for a genetic program and external stimuli is a key feature of sensory circuit formation. However, the contribution of cell-intrinsic codes to directing sensory-specific circuits remains unknown....
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Miyoshi G
Neurosci Res . 2018 Sep; 138:26-32. PMID: 30227162
GABAergic interneurons in the neocortex play pivotal roles in the feedforward and feedback inhibition that control higher order information processing and thus, malfunction in the inhibitory circuits often leads to...
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Yagasaki Y, Miyoshi G, Miyata M
PLoS One . 2018 May; 13(5):e0198268. PMID: 29847590
Loss or gain of copy number of the gene encoding the transcription factor methyl-CpG-binding protein 2 (MeCP2) leads to neurodevelopmental disorders (Rett and MeCP2 duplication syndrome), indicating that precisely regulated...
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Godbole G, Shetty A, Roy A, DSouza L, Chen B, Miyoshi G, et al.
Development . 2017 Dec; 145(1). PMID: 29229772
During forebrain development, a telencephalic organizer called the cortical hem is crucial for inducing hippocampal fate in adjacent cortical neuroepithelium. How the hem is restricted to its medial position is...