Prox1 Regulates the Subtype-Specific Development of Caudal Ganglionic Eminence-Derived GABAergic Cortical Interneurons

Overview

Journal J Neurosci

Specialty Neurology

Date 2015 Sep 18

PMID 26377473

Citations 66

Authors

Goichi Miyoshi

Allison Young

Timothy Petros

Theofanis Karayannis

Melissa McKenzie Chang

Alfonso Lavado

Tomohiko Iwano

Miho Nakajima

Hiroki Taniguchi

Z Josh Huang

Nathaniel Heintz

Guillermo Oliver

Fumio Matsuzaki

Robert P Machold

Gord Fishell

Affiliations

Soon will be listed here.

Abstract

Significance Statement: Despite the recognition that 30% of GABAergic cortical interneurons originate from the caudal ganglionic eminence (CGE), to date, a specific transcriptional program that selectively regulates the development of these populations has not yet been identified. Moreover, while CGE-derived interneurons display unique patterns of tangential and radial migration and preferentially populate the superficial layers of the cortex, identification of a molecular program that controls these events is lacking.Here, we demonstrate that the homeodomain transcription factor Prox1 is expressed in postmitotic CGE-derived cortical interneuron precursors and is maintained into adulthood. We found that Prox1 function is differentially required during both embryonic and postnatal stages of development to direct the migration, differentiation, circuit integration, and maintenance programs within distinct subtypes of CGE-derived interneurons.

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