Robert P Hausinger
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Explore the profile of Robert P Hausinger including associated specialties, affiliations and a list of published articles.
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119
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2916
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Recent Articles
1.
Chatterjee S, Rankin J, Farrugia M, J S Rifayee S, Christov C, Hu J, et al.
Biochemistry
. 2025 Mar;
PMID: 40052306
The ethylene-forming enzyme (EFE) from the fungus strain Pd1 was heterologously produced in and its properties were compared to the extensively characterized bacterial enzyme from strain PK2. Both enzymes catalyze...
2.
Gatreddi S, Urdiain-Arraiza J, Desguin B, Hausinger R, Hu J
ACS Catal
. 2025 Feb;
15(4):2857-2866.
PMID: 40013250
The LarA family consists of diverse racemases/epimerases that interconvert the diastereomers of α-hydroxyacids by using a nickel-pincer nucleotide (NPN) cofactor. The hidden redox reaction catalyzed by the NPN cofactor makes...
3.
Gatreddi S, Chatterjee S, Turmo A, Hu J, Hausinger R
Crit Rev Biochem Mol Biol
. 2025 Jan;
1-16.
PMID: 39827451
The nickel-pincer nucleotide (NPN) is an organometallic cofactor that was first discovered in lactate racemase from . In this review, we provide an overview on the structure-function relationships of enzymes...
4.
Nevarez J, Turmo A, Gatreddi S, Gupta S, Hu J, Hausinger R
mBio
. 2024 Dec;
16(2):e0340424.
PMID: 39679682
Importance: Enzymes containing the nickel-pincer nucleotide (NPN) cofactor are prevalent in a wide range of microorganisms and catalyze various critical biochemical reactions, yet they remain underexplored due, in part, to...
5.
Gatreddi S, Urdiain-Arraiza J, Desguin B, Hausinger R, Hu J
bioRxiv
. 2024 Dec;
PMID: 39651260
The LarA family consists of diverse racemases/epimerases that interconvert the diastereomers of a variety of α-hydroxyacids by using a nickel-pincer nucleotide (NPN) cofactor. The hidden redox reaction catalyzed by the...
6.
Chatterjee S, Fellner M, Rankin J, Thomas M, J S Rifayee S, Christov C, et al.
Biochemistry
. 2024 Apr;
63(8):1038-1050.
PMID: 38577885
The ethylene-forming enzyme (EFE) is an Fe(II), 2-oxoglutarate (2OG), and l-arginine (l-Arg)-dependent oxygenase that either forms ethylene and three CO/bicarbonate from 2OG or couples the decarboxylation of 2OG to C5...
7.
Guzior D, Okros M, Shivel M, Armwald B, Bridges C, Fu Y, et al.
Nature
. 2024 Feb;
626(8000):852-858.
PMID: 38326608
Bile acids (BAs) are steroid detergents in bile that contribute to the absorption of fats and fat-soluble vitamins while shaping the gut microbiome because of their antimicrobial properties. Here we...
8.
Hausinger R
Enzymes
. 2023 Nov;
54:71-105.
PMID: 37945178
Metalloenzymes have been detailed in The Enzymes since its inception over half a century ago. Here, I review selected metal-containing enzyme highlights from early chapters in this series and I...
9.
Gatreddi S, Sui D, Hausinger R, Hu J
ACS Catal
. 2023 Oct;
13(2):1441-1448.
PMID: 37886035
The nickel-pincer nucleotide (NPN) cofactor discovered in lactate racemase from (LarA) is essential for the activities of racemases/epimerases in the highly diverse LarA superfamily. Prior mechanistic studies have established a...
10.
Chatterjee S, Nevarez J, Rankin J, Hu J, Hausinger R
Biochemistry
. 2023 Oct;
62(21):3096-3104.
PMID: 37831946
LarB catalyzes the first step of biosynthesis for the nickel-pincer nucleotide cofactor by converting nicotinic acid adenine dinucleotide (NaAD) to AMP and pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN). Prior studies had shown...