Joel A Rankin
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Explore the profile of Joel A Rankin including associated specialties, affiliations and a list of published articles.
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9
Citations
53
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Recent Articles
1.
Chatterjee S, Rankin J, Farrugia M, J S Rifayee S, Christov C, Hu J, et al.
Biochemistry
. 2025 Mar;
PMID: 40052306
The ethylene-forming enzyme (EFE) from the fungus strain Pd1 was heterologously produced in and its properties were compared to the extensively characterized bacterial enzyme from strain PK2. Both enzymes catalyze...
2.
Tassoulas L, Rankin J, Elias M, Wackett L
Proc Natl Acad Sci U S A
. 2024 Feb;
121(10):e2312652121.
PMID: 38408229
Metformin is the first-line treatment for type II diabetes patients and a pervasive pollutant with more than 180 million kg ingested globally and entering wastewater. The drug's direct mode of...
3.
Chatterjee S, Nevarez J, Rankin J, Hu J, Hausinger R
Biochemistry
. 2023 Oct;
62(21):3096-3104.
PMID: 37831946
LarB catalyzes the first step of biosynthesis for the nickel-pincer nucleotide cofactor by converting nicotinic acid adenine dinucleotide (NaAD) to AMP and pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN). Prior studies had shown...
4.
Chaturvedi S, Rifayee S, Ramanan R, Rankin J, Hu J, Hausinger R, et al.
Phys Chem Chem Phys
. 2023 May;
25(19):13772-13783.
PMID: 37159254
The non-heme Fe(II) and 2-oxoglutarate (2OG) dependent ethylene-forming enzyme (EFE) catalyzes both ethylene generation and L-Arg hydroxylation. Despite experimental and computational progress in understanding the mechanism of EFE, no EFE...
5.
Chatterjee S, Gatreddi S, Gupta S, Nevarez J, Rankin J, Turmo A, et al.
Biochem Soc Trans
. 2022 Aug;
50(4):1187-1196.
PMID: 35960008
The nickel-pincer nucleotide (NPN) coenzyme, a substituted pyridinium mononucleotide that tri-coordinates nickel, was first identified covalently attached to a lysine residue in the LarA protein of lactate racemase. Starting from...
6.
Rankin J, Chatterjee S, Tariq Z, Lagishetty S, Desguin B, Hu J, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(39).
PMID: 34548397
Enzymes possessing the nickel-pincer nucleotide (NPN) cofactor catalyze C2 racemization or epimerization reactions of α-hydroxyacid substrates. LarB initiates synthesis of the NPN cofactor from nicotinic acid adenine dinucleotide (NaAD) by...
7.
Fellner M, Rankin J, Desguin B, Hu J, Hausinger R
Biochemistry
. 2018 Aug;
57(38):5513-5523.
PMID: 30157639
LarE from Lactobacillus plantarum is an ATP-dependent sulfur transferase that sacrifices its Cys176 sulfur atom to form a dehydroalanine (Dha) side chain during biosynthesis of the covalently linked nickel-pincer nucleotide...
8.
Hausinger R, Desguin B, Fellner M, Rankin J, Hu J
Curr Opin Chem Biol
. 2018 Jul;
47:18-23.
PMID: 30015232
A novel organometallic cofactor, nickel pyridinium-3,5-dithiocarboxylic acid mononucleotide, was recently discovered in lactate racemase (LarA) of Lactobacillus plantarum. This review summarizes the substantial progress made in uncovering the function of...
9.
Rankin J, Mauban R, Fellner M, Desguin B, McCracken J, Hu J, et al.
Biochemistry
. 2018 Mar;
57(23):3244-3251.
PMID: 29489337
Lactate racemase (LarA) of Lactobacillus plantarum contains a novel organometallic cofactor with nickel coordinated to a covalently tethered pincer ligand, pyridinium-3-thioamide-5-thiocarboxylic acid mononucleotide, but its function in the enzyme mechanism...
10.
Sutherland M, Rankin J, Kranz R
Biochemistry
. 2016 May;
55(22):3150-6.
PMID: 27198710
Cytochromes c require covalent attachment of heme via two thioether bonds at conserved CXXCH motifs, a process accomplished in prokaryotes by eight integral membrane proteins (CcmABCDEFGH), termed System I. Heme...