Robert OHagan
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Explore the profile of Robert OHagan including associated specialties, affiliations and a list of published articles.
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20
Citations
764
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Recent Articles
1.
OHagan R, Avrutis A, Ramicevic E
Mol Cell Neurosci
. 2022 Nov;
123:103790.
PMID: 36368428
Due to their elongated and polarized morphology, neurons rely on the microtubule (MT) cytoskeleton for their shape, as well as for efficient intracellular transport that maintains neuronal function, survival, and...
2.
OHagan R, Topalidou I
Bio Protoc
. 2021 Nov;
11(19):e4172.
PMID: 34722819
Although the advent of genetically-encoded fluorescent markers, such as the green fluorescent protein (GFP; Chalfie , 1994 ), has enabled convenient visualization of gene expression , this method is generally...
3.
Ramadan Y, Gu A, Ross N, McEwan S, Barr M, Firestein B, et al.
eNeuro
. 2021 Mar;
8(2).
PMID: 33688040
Microtubules (MTs) are cytoskeletal elements that provide structural support and act as roadways for intracellular transport in cells. MTs are also needed for neurons to extend and maintain long axons...
4.
Power K, Akella J, Gu A, Walsh J, Bellotti S, Morash M, et al.
PLoS Genet
. 2020 Oct;
16(10):e1009052.
PMID: 33064774
Ciliary microtubules are subject to post-translational modifications that act as a "Tubulin Code" to regulate motor traffic, binding proteins and stability. In humans, loss of CCP1, a cytosolic carboxypeptidase and...
5.
OHagan R, Silva M, Nguyen K, Zhang W, Bellotti S, Ramadan Y, et al.
Curr Biol
. 2017 Nov;
27(22):3430-3441.e6.
PMID: 29129530
Ciliary microtubules (MTs) are extensively decorated with post-translational modifications (PTMs), such as glutamylation of tubulin tails. PTMs and tubulin isotype diversity act as a "tubulin code" that regulates cytoskeletal stability...
6.
Lockhead D, Schwarz E, OHagan R, Bellotti S, Krieg M, Barr M, et al.
Mol Biol Cell
. 2016 Sep;
PMID: 27654945
Microtubules contribute to many cellular processes, including transport, signaling, and chromosome separation during cell division (Kapitein and Hoogenraad, 2015). They are comprised of αβ-tubulin heterodimers arranged into linear protofilaments and...
7.
Kymographic Analysis of Transport in an Individual Neuronal Sensory Cilium in Caenorhabditis elegans
OHagan R, Barr M
Methods Mol Biol
. 2016 Aug;
1454:107-22.
PMID: 27514919
Intraflagellar Transport (IFT) is driven by molecular motors that travel upon microtubule-based ciliary axonemes. In the single-celled alga Chlamydomonas reinhardtii, movement of a single anterograde IFT motor, heterotrimeric kinesin-II, is...
8.
Chen Y, Bharill S, OHagan R, Isacoff E, Chalfie M
G3 (Bethesda)
. 2016 May;
6(4):1121-30.
PMID: 27172609
The Caenorhabditis elegans DEG/ENaC proteins MEC-4 and MEC-10 transduce gentle touch in the six touch receptor neurons . Gain-of-function mutations of mec-4 and mec-4(d) result in a hyperactive channel and...
9.
Chen Y, Bharill S, Altun Z, OHagan R, Coblitz B, Isacoff E, et al.
Mol Biol Cell
. 2016 Mar;
27(8):1272-85.
PMID: 26941331
Caenorhabditis eleganssenses gentle touch via a mechanotransduction channel formed from the DEG/ENaC proteins MEC-4 and MEC-10. An additional protein, the paraoxonase-like protein MEC-6, is essential for transduction, and previous work...
10.
OHagan R, Barr M
Nat Cell Biol
. 2015 Nov;
17(12):1517-9.
PMID: 26612573
A powerful combination of two-colour imaging in vivo, Fourier-filtered kymography and simulations provides a high-resolution view of kinesin-2 transport dynamics in cilia. This study reveals heterotrimeric kinesin-II as an 'obstacle-course...