Ehud Y Isacoff
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Explore the profile of Ehud Y Isacoff including associated specialties, affiliations and a list of published articles.
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149
Citations
7298
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Recent Articles
1.
Vendrell-Llopis N, Read J, Boggiano S, Hetzler B, Peitsinis Z, Stanley C, et al.
Neuron
. 2025 Jan;
113(5):785-794.e9.
PMID: 39814009
Timed dopamine signals underlie reinforcement learning, favoring neural activity patterns that drive behaviors with positive outcomes. In the striatum, dopamine activates five dopamine receptors (D1R-D5R), which are differentially expressed in...
2.
Bakshinska D, Liu W, Schultz R, Stowers R, Hoagland A, Cypranowska C, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2420496121.
PMID: 39793084
Norepinephrine in vertebrates and its invertebrate analog, octopamine, regulate the activity of neural circuits. We find that, when hungry, larvae switch activity in type II octopaminergic motor neurons (MNs) to...
3.
Aghi K, Schultz R, Newman Z, Mendonca P, Li R, Bakshinska D, et al.
bioRxiv
. 2024 Sep;
PMID: 39314438
Basal synaptic strength can vary greatly between synapses formed by an individual neuron because of diverse probabilities of action potential (AP) evoked transmitter release ( ). Optical quantal analysis on...
4.
Cypranowska C, Bakshinska D, Feldthouse M, Choi Y, Li R, Newman Z, et al.
bioRxiv
. 2024 Sep;
PMID: 39257793
Weakening of synaptic transmission at the Drosophila larval neuromuscular junction triggers two forms of homeostatic compensation, one that increases the probability of glutamate release per action potential (Pr) and another...
5.
Hoagland A, Newman Z, Cai Z, Isacoff E
bioRxiv
. 2024 Sep;
PMID: 39253468
Homeostatic regulation of excitability and synaptic transmission ensures stable neural circuit output under changing conditions. We find that pre- or postsynaptic weakening of motor neuron (MN) to muscle glutamatergic transmission...
6.
Bleier J, Furtado de Mendonca P, Habrian C, Stanley C, Vyklicky V, Isacoff E
Cell Rep
. 2024 Aug;
43(8):114634.
PMID: 39154344
N-methyl-D-aspartate receptors are ionotropic glutamate receptors that mediate synaptic transmission and plasticity. Variable GluN2 subunits in diheterotetrameric receptors with identical GluN1 subunits set very different functional properties. To understand this...
7.
Yu Y, Zhang L, Li B, Fu Z, Brohawn S, Isacoff E
Nat Commun
. 2024 Jul;
15(1):6409.
PMID: 39080263
Voltage-sensing phosphatases (VSPs) dephosphorylate phosphoinositide (PIP) signaling lipids in response to membrane depolarization. VSPs possess an S4-containing voltage sensor domain (VSD), resembling that of voltage-gated cation channels, and a lipid...
8.
Deal P, Lee H, Mondal A, Lolicato M, Furtado de Mendonca P, Black H, et al.
Cell Chem Biol
. 2024 Jul;
31(7):1305-1323.e9.
PMID: 39029456
K potassium channels regulate excitability by affecting cellular resting membrane potential in the brain, cardiovascular system, immune cells, and sensory organs. Despite their important roles in anesthesia, arrhythmia, pain, hypertension,...
9.
Kumar K, Wang H, Habrian C, Latorraca N, Xu J, OBrien E, et al.
Nature
. 2024 May;
629(8013):E13.
PMID: 38702522
No abstract available.
10.
Kumar K, Wang H, Habrian C, Latorraca N, Xu J, OBrien E, et al.
Nature
. 2024 Apr;
629(8013):951-956.
PMID: 38632403
Metabotropic glutamate receptors belong to a family of G protein-coupled receptors that are obligate dimers and possess a large extracellular ligand-binding domain that is linked via a cysteine-rich domain to...