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Robert M Brownstone

Explore the profile of Robert M Brownstone including associated specialties, affiliations and a list of published articles. Areas
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Articles 61
Citations 1807
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Recent Articles
1.
Smith C, Nascimento F, Ozyurt M, Beato M, Brownstone R
iScience . 2024 Aug; 27(8):110444. PMID: 39148717
The increased muscular force output required for some behaviors is achieved via amplification of motoneuron output via cholinergic C-bouton synapses. Work in neonatal mouse motoneurons suggested that modulation of currents...
2.
Ozyurt M, Nascimento F, Brownstone R, Beato M
Brain . 2023 Oct; 147(2):406-413. PMID: 37796028
Neurophysiological methods are used widely to gain information about motor neuron excitability and axon conduction in neurodegenerative diseases. The F-wave is a common biomarker used to test motor neuron properties...
3.
Pocratsky A, Nascimento F, Ozyurt M, White I, Sullivan R, OCallaghan B, et al.
Sci Transl Med . 2023 May; 15(694):eadg3904. PMID: 37134150
Dystonia, a neurological disorder defined by abnormal postures and disorganized movements, is considered to be a neural circuit disorder with dysfunction arising within and between multiple brain regions. Given that...
4.
Ronzano R, Skarlatou S, Barriga B, Bannatyne B, Bhumbra G, Foster J, et al.
Elife . 2022 Dec; 11. PMID: 36512397
Elaborate behaviours are produced by tightly controlled flexor-extensor motor neuron activation patterns. Motor neurons are regulated by a network of interneurons within the spinal cord, but the computational processes involved...
5.
Shetty A, Delanerolle G, Zeng Y, Shi J, Ebrahim R, Pang J, et al.
Front Digit Health . 2022 Nov; 4:850601. PMID: 36405414
Importance: Pain is a silent global epidemic impacting approximately a third of the population. Pharmacological and surgical interventions are primary modes of treatment. Cognitive/behavioural management approaches and interventional pain management...
6.
Smith C, Brownstone R
Adv Neurobiol . 2022 Sep; 28:191-232. PMID: 36066827
Motoneurons are the 'final common path' between the central nervous system (that intends, selects, commands, and organises movement) and muscles (that produce the behaviour). Motoneurons are not passive relays, but...
7.
Thiry L, Lemaire C, Rastqar A, Lemieux M, Peng J, Ferent J, et al.
eNeuro . 2022 Feb; 9(2). PMID: 35115383
Axon guidance receptors such as deleted in colorectal cancer (DCC) contribute to the normal formation of neural circuits, and their mutations can be associated with neural defects. In humans, heterozygous...
8.
Ronzano R, Lancelin C, Bhumbra G, Brownstone R, Beato M
Elife . 2021 Nov; 10. PMID: 34727018
Motoneurons (MNs) control muscle contractions, and their recruitment by premotor circuits is tuned to produce accurate motor behaviours. To understand how these circuits coordinate movement across and between joints, it...
9.
Chopek J, Zhang Y, Brownstone R
J Neurophysiol . 2021 Oct; 126(6):1978-1990. PMID: 34669520
Glutamatergic reticulospinal neurons in the gigantocellular reticular nucleus (GRN) of the medullary reticular formation can function as command neurons, transmitting motor commands to spinal cord circuits to instruct movement. Recent...
10.
Koronfel L, Kanning K, Alcos A, Henderson C, Brownstone R
Sci Rep . 2021 Aug; 11(1):16008. PMID: 34362940
The spinal cord contains neural circuits that can produce the rhythm and pattern of locomotor activity. It has previously been postulated that a population of glutamatergic neurons, termed Hb9 interneurons,...