Robert Kuhnert
Overview
Explore the profile of Robert Kuhnert including associated specialties, affiliations and a list of published articles.
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11
Citations
125
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Recent Articles
1.
Kuhnert L, Kuhnert R, Sarosi M, Lakoma C, Scholz B, Lonnecke P, et al.
Mol Oncol
. 2023 Sep;
18(2):280-290.
PMID: 37727134
Success of chemotherapy is often hampered by multidrug resistance. One mechanism for drug resistance is the elimination of anticancer drugs through drug transporters, such as breast cancer resistance protein (BCRP;...
2.
Paskas S, Murganic B, Kuhnert R, Hey-Hawkins E, Mijatovic S, Maksimovic-Ivanic D
Molecules
. 2022 Jul;
27(14).
PMID: 35889376
Lipoxygenases convert polyunsaturated fatty acids into biologically active metabolites such as inflammatory mediators-prostaglandins and leukotrienes. The inhibition of lipoxygenases is increasingly employed in the treatment of cancer. We evaluated the...
3.
Fichtel P, von Bonin M, Kuhnert R, Mobus K, Bornhauser M, Wobus M
Front Bioeng Biotechnol
. 2022 Jun;
10:892661.
PMID: 35721867
Aging of the hematopoietic system is characterized by an expansion of hematopoietic stem and progenitor cells (HSPCs) with reduced capacity for engraftment, self-renewal, and lymphoid differentiation, resulting in myeloid-biased hematopoiesis....
4.
Kuhnert R, Kuhnert L, Sarosi M, George S, Draca D, Paskas S, et al.
ChemMedChem
. 2021 Oct;
17(1):e202100588.
PMID: 34694057
12-Lipoxygenase is crucial for tumour angiogenesis. 5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one (baicalein) is a suitable inhibitor for this enzyme but is rapidly metabolised in vivo. Thus, an improvement of the metabolic stability is necessary...
5.
Hoppenz P, Els-Heindl S, Kellert M, Kuhnert R, Saretz S, Lerchen H, et al.
J Org Chem
. 2019 Dec;
85(3):1446-1457.
PMID: 31813224
Boron neutron capture therapy (BNCT) allows the selective elimination of malignant tumor cells without affecting healthy tissue. Although this binary radiotherapy approach has been known for decades, BNCT failed to...
6.
Worm D, Hoppenz P, Els-Heindl S, Kellert M, Kuhnert R, Saretz S, et al.
J Med Chem
. 2019 Oct;
63(5):2358-2371.
PMID: 31589041
G-protein-coupled receptors like the human Y receptor (hYR) are promising targets in cancer therapy due to their high overexpression on cancer cells and their ability to internalize together with the...
7.
Stockmann P, Gozzi M, Kuhnert R, Sarosi M, Hey-Hawkins E
Chem Soc Rev
. 2019 Jun;
48(13):3497-3512.
PMID: 31214680
Icosahedral carboranes in medicine are still an emerging class of compounds with potential beneficial applications in drug design. These highly hydrophobic clusters are potential "new keys for old locks" which...
8.
Kuhnert R, Sarosi M, George S, Lonnecke P, Hofmann B, Steinhilber D, et al.
ChemMedChem
. 2018 Nov;
14(2):255-261.
PMID: 30471171
5-Lipoxygenase converts arachidonic acid into leukotrienes, which are involved in inflammation and angiogenesis. The introduction of carboranes can improve the pharmacokinetic behavior of metabolically less stable pharmaceutics. Herein we report...
9.
Worm D, Els-Heindl S, Kellert M, Kuhnert R, Saretz S, Koebberling J, et al.
J Pept Sci
. 2018 Sep;
24(10):e3119.
PMID: 30168238
Boron neutron capture therapy (BNCT) is a binary cancer therapy, which combines the biochemical targeting of a boron-containing drug with the regional localization of radiation treatment. Although the concept of...
10.
Kuhnert R, Sarosi M, George S, Lonnecke P, Hofmann B, Steinhilber D, et al.
ChemMedChem
. 2017 Jun;
12(13):1081-1086.
PMID: 28569429
The progression of cancer is accelerated by increased proliferation, angiogenesis, and inflammation. These processes are mediated by leukotrienes. Several cancer cell lines overexpress 5-lipoxygenase, an enzyme that converts arachidonic acid...