Robert J Weatheritt
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Explore the profile of Robert J Weatheritt including associated specialties, affiliations and a list of published articles.
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3981
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Recent Articles
11.
Santos-Rodriguez G, Voineagu I, Weatheritt R
Elife
. 2021 Sep;
10.
PMID: 34542404
Many primate genes produce circular RNAs (circRNAs). However, the extent of circRNA conservation between closely related species remains unclear. By comparing tissue-specific transcriptomes across over 70 million years of primate...
12.
Differential contribution of transcriptomic regulatory layers in the definition of neuronal identity
Ha K, Sterne-Weiler T, Morris Q, Weatheritt R, Blencowe B
Nat Commun
. 2021 Jan;
12(1):335.
PMID: 33436550
Previous transcriptomic profiling studies have typically focused on separately analyzing mRNA expression, alternative splicing and alternative polyadenylation differences between cell and tissue types. However, the relative contribution of these three...
13.
Farini D, Cesari E, Weatheritt R, La Sala G, Naro C, Pagliarini V, et al.
Cell Rep
. 2020 Jun;
31(9):107703.
PMID: 32492419
Tight coordination of gene expression in the developing cerebellum is crucial for establishment of neuronal circuits governing motor and cognitive function. However, transcriptional changes alone do not explain all of...
14.
Luck K, Kim D, Lambourne L, Spirohn K, Begg B, Bian W, et al.
Nature
. 2020 Apr;
580(7803):402-408.
PMID: 32296183
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships. Here we present a human 'all-by-all' reference interactome map of human...
15.
Rodrigues D, Mufteev M, Weatheritt R, Djuric U, Ha K, Ross P, et al.
Cell Rep
. 2020 Mar;
30(12):4179-4196.e11.
PMID: 32209477
Regulation of translation during human development is poorly understood, and its dysregulation is associated with Rett syndrome (RTT). To discover shifts in mRNA ribosomal engagement (RE) during human neurodevelopment, we...
16.
Gonatopoulos-Pournatzis T, Niibori R, Salter E, Weatheritt R, Tsang B, Farhangmehr S, et al.
Mol Cell
. 2020 Jan;
77(6):1176-1192.e16.
PMID: 31999954
Microexons represent the most highly conserved class of alternative splicing, yet their functions are poorly understood. Here, we focus on closely related neuronal microexons overlapping prion-like domains in the translation...
17.
Avgan N, Wang J, Fernandez-Chamorro J, Weatheritt R
Genome Biol
. 2019 Jul;
20(1):141.
PMID: 31315652
Background: The long introns of mammals are pools of evolutionary potential due to the multiplicity of sequences that permit the acquisition of novel exons. However, the permissibility of genes to...
18.
Quesnel-Vallieres M, Weatheritt R, Cordes S, Blencowe B
Nat Rev Genet
. 2018 Nov;
20(1):51-63.
PMID: 30390048
Heredity has a major role in autism spectrum disorder (ASD), yet underlying causal genetic variants have been defined only in a fairly small subset of cases. The enormous genetic heterogeneity...
19.
Sterne-Weiler T, Weatheritt R, Best A, Ha K, Blencowe B
Mol Cell
. 2018 Sep;
72(1):187-200.e6.
PMID: 30220560
Alternative splicing (AS) is a widespread process underlying the generation of transcriptomic and proteomic diversity and is frequently misregulated in human disease. Accordingly, an important goal of biomedical research is...
20.
Gueroussov S, Weatheritt R, OHanlon D, Lin Z, Narula A, Gingras A, et al.
Cell
. 2017 Jul;
170(2):324-339.e23.
PMID: 28709000
Alternative splicing (AS) patterns have diverged rapidly during vertebrate evolution, yet the functions of most species- and lineage-specific splicing events are not known. We observe that mammalian-specific AS events are...