Robert J Cousins
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Explore the profile of Robert J Cousins including associated specialties, affiliations and a list of published articles.
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45
Citations
2775
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Recent Articles
1.
Jimenez-Rondan F, Ruggiero C, Riva A, Yu F, Stafford L, Cross T, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2422321121.
PMID: 39793074
Documented worldwide, impaired immunity is a cardinal signature resulting from loss of dietary zinc, an essential micronutrient. A steady supply of zinc to meet cellular requirements is regulated by an...
2.
Jimenez-Rondan F, Ruggiero C, McKinley K, Koh J, Roberts J, Triplett E, et al.
Am J Physiol Gastrointest Liver Physiol
. 2022 Dec;
324(3):G159-G176.
PMID: 36537699
Zinc has anti-inflammatory properties using mechanisms that are unclear. Zip14 (Slc39a14) is a zinc transporter induced by proinflammatory stimuli and is highly expressed at the basolateral membrane of intestinal epithelial...
3.
Jimenez-Rondan F, Ruggiero C, Cousins R
Nutrients
. 2022 Dec;
14(23).
PMID: 36501144
Integration of non-coding RNAs and miRNAs with physiological processes in animals, including nutrient metabolism, is an important new focus. Twenty-three transporter proteins control cellular zinc homeostasis. The transporter Zip14 (Slc39a14)...
4.
Lin M, Colon-Perez L, Sambo D, Miller D, Lebowitz J, Jimenez-Rondan F, et al.
J Neurosci
. 2020 Jun;
40(30):5871-5891.
PMID: 32576620
Manganese exposure produces Parkinson's-like neurologic symptoms, suggesting a selective dysregulation of dopamine transmission. It is unknown, however, how manganese accumulates in dopaminergic brain regions or how it regulates the activity...
5.
Kim J, Aydemir T, Jimenez-Rondan F, Ruggiero C, Kim M, Cousins R
Sci Rep
. 2020 Mar;
10(1):4050.
PMID: 32132660
Skeletal muscle represents the largest pool of body zinc, however, little is known about muscle zinc homeostasis or muscle-specific zinc functions. Zip14 (Slc39a14) was the most highly expressed zinc transporter...
6.
Aydemir T, Thorn T, Ruggiero C, Pompilus M, Febo M, Cousins R
Am J Physiol Gastrointest Liver Physiol
. 2020 Feb;
318(4):G673-G681.
PMID: 32003605
Impaired manganese (Mn) homeostasis can result in excess Mn accumulation in specific brain regions and neuropathology. Maintaining Mn homeostasis and detoxification is dependent on effective Mn elimination. Specific metal transporters...
7.
Hendrickx G, Borra V, Steenackers E, Yorgan T, Hermans C, Boudin E, et al.
PLoS Genet
. 2018 Apr;
14(4):e1007321.
PMID: 29621230
Hyperostosis Cranialis Interna (HCI) is a rare bone disorder characterized by progressive intracranial bone overgrowth at the skull. Here we identified by whole-exome sequencing a dominant mutation (L441R) in SLC39A14...
8.
Aydemir T, Cousins R
J Nutr
. 2018 Mar;
148(2):174-184.
PMID: 29490098
The SLC39A family of metal transporters was identified through homologies with the Zrt- and Irt-like (ZIP) proteins from yeast and plants. Of all the ZIP transporters, ZIP14 is arguably the...
9.
Kim M, Aydemir T, Kim J, Cousins R
Proc Natl Acad Sci U S A
. 2017 Jul;
114(29):E5805-E5814.
PMID: 28673968
Extensive endoplasmic reticulum (ER) stress damages the liver, causing apoptosis and steatosis despite the activation of the unfolded protein response (UPR). Restriction of zinc from cells can induce ER stress,...
10.
Aydemir T, Kim M, Kim J, Colon-Perez L, Banan G, Mareci T, et al.
J Neurosci
. 2017 May;
37(25):5996-6006.
PMID: 28536273
Mutations in human have been linked to symptoms of the early onset of Parkinsonism and Dystonia. This phenotype is likely related to excess manganese accumulation in the CNS. The metal...