Robert J Cardnell
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Explore the profile of Robert J Cardnell including associated specialties, affiliations and a list of published articles.
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25
Citations
1460
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Recent Articles
1.
Serrano A, Rocha P, Lima C, Stewart A, Zhang B, Diao L, et al.
NPJ Precis Oncol
. 2024 Nov;
8(1):268.
PMID: 39558076
Delta-like Ligand 3 (DLL3) targeting therapies are promising in small cell lung cancer (SCLC) treatment. However, DLL3 expression in SCLC and other neuroendocrine neoplasms (NEN) is heterogeneous and not well...
2.
Morris B, Heeke S, Xi Y, Diao L, Wang Q, Rocha P, et al.
bioRxiv
. 2024 Aug;
PMID: 39211077
Introduction: A hallmark of small cell lung cancer (SCLC) is its recalcitrance to therapy. While most SCLCs respond to frontline therapy, resistance inevitably develops. Identifying phenotypes potentiating chemoresistance and immune...
3.
Stewart C, Diao L, Xi Y, Wang R, Ramkumar K, Serrano A, et al.
Clin Cancer Res
. 2024 Aug;
30(20):4743-4754.
PMID: 39150543
Purpose: Large cell neuroendocrine carcinoma (LCNEC) is a high-grade neuroendocrine malignancy that, like small cell lung cancer (SCLC), is associated with the absence of druggable oncogenic drivers and dismal prognosis....
4.
Zhang B, Lewis W, Stewart C, Morris B, Solis L, Serrano A, et al.
JTO Clin Res Rep
. 2024 Feb;
5(2):100623.
PMID: 38357092
Introduction: NSCLC transformation to SCLC has been best characterized with -mutant NSCLC, with emerging case reports seen in , , and -altered NSCLC. Previous reports revealed transformed SCLC from -mutant...
5.
Ramkumar K, Tanimoto A, Della Corte C, Stewart C, Wang Q, Shen L, et al.
Clin Cancer Res
. 2023 Jun;
29(16):3237-3249.
PMID: 37289191
Purpose: Therapeutic resistance to frontline therapy develops rapidly in small cell lung cancer (SCLC). Treatment options are also limited by the lack of targetable driver mutations. Therefore, there is an...
6.
Zhang B, Stewart C, Wang Q, Cardnell R, Rocha P, Fujimoto J, et al.
Br J Cancer
. 2022 Apr;
127(3):569-576.
PMID: 35440668
Introduction: Small cell lung cancer (SCLC) is an aggressive malignancy with no established biomarkers. Schlafen 11(SLFN11), a DNA/RNA helicase that sensitises cancer cells to DNA-damaging agents, has emerged as a...
7.
Kundu K, Cardnell R, Zhang B, Shen L, Stewart C, Ramkumar K, et al.
Transl Lung Cancer Res
. 2022 Jan;
10(11):4095-4105.
PMID: 35004241
Background: Lurbinectedin recently received FDA accelerated approval as a second line treatment option for metastatic small cell lung cancer (SCLC). However, there are currently no established biomarkers to predict SCLC...
8.
Cargill K, Stewart C, Park E, Ramkumar K, Gay C, Cardnell R, et al.
Cancer Metab
. 2021 Sep;
9(1):33.
PMID: 34556188
Introduction: The transcription factor MYC is overexpressed in 30% of small cell lung cancer (SCLC) tumors and is known to modulate the balance between two major pathways of metabolism: glycolysis...
9.
Stewart C, Gay C, Ramkumar K, Cargill K, Cardnell R, Nilsson M, et al.
J Thorac Oncol
. 2021 Jul;
16(11):1821-1839.
PMID: 34274504
Introduction: Coronavirus disease 2019 is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which enters host cells through the cell surface proteins ACE2 and TMPRSS2. Methods:...
10.
Gay C, Stewart C, Park E, Diao L, Groves S, Heeke S, et al.
Cancer Cell
. 2021 Jan;
39(3):346-360.e7.
PMID: 33482121
Despite molecular and clinical heterogeneity, small cell lung cancer (SCLC) is treated as a single entity with predictably poor results. Using tumor expression data and non-negative matrix factorization, we identify...