Robert H Costa
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Explore the profile of Robert H Costa including associated specialties, affiliations and a list of published articles.
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56
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Recent Articles
1.
Wang Z, Park H, Carr J, Chen Y, Zheng Y, Li J, et al.
Cancer Res
. 2011 Apr;
71(12):4292-302.
PMID: 21507930
Malignant neuroblastomas contain stem-like cells. These tumors also overexpress the Forkhead box transcription factor FoxM1. In this study, we investigated the roles of FoxM1 in the tumorigenicity of neuroblastoma. We...
2.
Park H, Gusarova G, Wang Z, Carr J, Li J, Kim K, et al.
EMBO Mol Med
. 2011 Jan;
3(1):21-34.
PMID: 21204266
The forkhead box M1b (FoxM1b) transcription factor is over-expressed in human cancers, and its expression often correlates with poor prognosis. Previously, using conditional knockout strains, we showed that FoxM1b is...
3.
Petrovic V, Costa R, Lau L, Raychaudhuri P, Tyner A
Cancer Biol Ther
. 2010 Apr;
9(12):1008-16.
PMID: 20372080
The Forkhead Box transcription factor FoxM1 regulates expression of genes that promote cell cycle progression, and it plays essential roles in the development of liver, lung, prostate and colorectal tumors....
4.
Zhang H, Ables E, Pope C, Washington M, Hipkens S, Means A, et al.
Mech Dev
. 2009 Sep;
126(11-12):958-73.
PMID: 19766716
Within the developing pancreas Hepatic Nuclear Factor 6 (HNF6) directly activates the pro-endocrine transcription factor, Ngn3. HNF6 and Ngn3 are each essential for endocrine differentiation and HNF6 is also required...
5.
Chen Y, Dominguez-Brauer C, Wang Z, Asara J, Costa R, Tyner A, et al.
J Biol Chem
. 2009 Sep;
284(44):30695-707.
PMID: 19737929
The Forkhead box M1 (FoxM1) transcription factor is critical for expression of the genes essential for G(1)/S transition and mitotic progression. To explore the cell cycle regulation of FoxM1, we...
6.
Park H, Carr J, Wang Z, Nogueira V, Hay N, Tyner A, et al.
EMBO J
. 2009 Aug;
28(19):2908-18.
PMID: 19696738
The transcription factor FoxM1 is over-expressed in most human malignancies. Although it is evident that FoxM1 has critical functions in tumour development and progression, the mechanisms by which FoxM1 participates...
7.
Misfeldt A, Costa R, Gannon M
Diabetes
. 2008 Aug;
57(11):3069-77.
PMID: 18728229
Objective: This study was designed to determine whether the transcription factor FoxM1 was required for regeneration of beta-cell mass via proliferation and/or neogenesis in the adult after 60% partial pancreatectomy...
8.
Park H, Costa R, Lau L, Tyner A, Raychaudhuri P
Mol Cell Biol
. 2008 Jun;
28(17):5162-71.
PMID: 18573889
The forkhead box M1 (FoxM1) transcription factor is overexpressed in many cancers, and in mouse models it is required for tumor progression. FoxM1 activates expression of the cell cycle genes...
9.
Wang I, Chen Y, Hughes D, Ackerson T, Major M, Kalinichenko V, et al.
J Biol Chem
. 2008 Jun;
283(30):20770-8.
PMID: 18524773
The Forkhead box M1 (FoxM1) protein is a proliferation-specific transcription factor that plays a key role in controlling both the G(1)/S and G(2)/M transitions through the cell cycle and is...
10.
Petrovic V, Costa R, Lau L, Raychaudhuri P, Tyner A
J Biol Chem
. 2007 Nov;
283(1):453-460.
PMID: 17984092
The Forkhead box M1 (FoxM1) transcription factor is essential for cell cycle progression and mitosis. FoxM1 regulates expression of Skp2 and Cks1, subunits of the SCF ubiquitin ligase complex, which...