Robert G Lloyd
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Explore the profile of Robert G Lloyd including associated specialties, affiliations and a list of published articles.
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50
Citations
1964
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Recent Articles
1.
Midgley-Smith S, Dimude J, Taylor T, Forrester N, Upton A, Lloyd R, et al.
Nucleic Acids Res
. 2018 Jul;
46(15):7701-7715.
PMID: 29982635
Chromosome duplication initiates via the assembly of replication forks at defined origins. Forks proceed in opposite directions until they fuse with a converging fork. Recent work highlights that fork fusions...
2.
Myka K, Hawkins M, Syeda A, Gupta M, Meharg C, Dillingham M, et al.
Nucleic Acids Res
. 2016 Dec;
45(5):2571-2584.
PMID: 27956500
Conflicts between replication and transcription challenge chromosome duplication. Escherichia coli replisome movement along transcribed DNA is promoted by Rep and UvrD accessory helicases with Δrep ΔuvrD cells being inviable under...
3.
Syeda A, Atkinson J, Lloyd R, McGlynn P
Genes (Basel)
. 2016 Aug;
7(8).
PMID: 27483323
Accessory replicative helicases aid the primary replicative helicase in duplicating protein-bound DNA, especially transcribed DNA. Recombination enzymes also aid genome duplication by facilitating the repair of DNA lesions via strand...
4.
Lloyd R, Rudolph C
Curr Genet
. 2016 Apr;
62(4):827-840.
PMID: 27038615
The RecG protein of Escherichia coli is a double-stranded DNA translocase that unwinds a variety of branched substrates in vitro. Although initially associated with homologous recombination and DNA repair, studies...
5.
Upton A, Grove J, Mahdi A, Briggs G, Milner D, Rudolph C, et al.
Nucleic Acids Res
. 2014 Apr;
42(9):5702-14.
PMID: 24692661
RecG is a DNA translocase encoded by most species of bacteria. The Escherichia coli protein targets branched DNA substrates and drives the unwinding and rewinding of DNA strands. Its ability...
6.
Rudolph C, Upton A, Stockum A, Nieduszynski C, Lloyd R
Nature
. 2013 Jul;
500(7464):608-11.
PMID: 23892781
Chromosome duplication normally initiates through the assembly of replication fork complexes at defined origins. DNA synthesis by any one fork is thought to cease when it meets another travelling in...
7.
Gupta M, Guy C, Yeeles J, Atkinson J, Bell H, Lloyd R, et al.
Proc Natl Acad Sci U S A
. 2013 Apr;
110(18):7252-7.
PMID: 23589869
Replication fork pausing drives genome instability, because any loss of paused replisome activity creates a requirement for reloading of the replication machinery, a potentially mutagenic process. Despite this importance, the...
8.
Mahdi A, Briggs G, Lloyd R
Mol Microbiol
. 2012 Sep;
86(3):675-91.
PMID: 22957744
RecG is a DNA translocase that helps to maintain genomic integrity. Initial studies suggested a role in promoting recombination, a possibility consistent with synergism between recG and ruv null alleles...
9.
Stockum A, Lloyd R, Rudolph C
BMC Microbiol
. 2012 Mar;
12:26.
PMID: 22373098
Background: Manipulations of the DNA double helix during replication, transcription and other nucleic acid processing cause a change of DNA topology, which results in torsional stress. This stress is relaxed...
10.
Atkinson J, Gupta M, Rudolph C, Bell H, Lloyd R, McGlynn P
Nucleic Acids Res
. 2010 Oct;
39(3):949-57.
PMID: 20923786
Genome duplication requires accessory helicases to displace proteins ahead of advancing replication forks. Escherichia coli contains three helicases, Rep, UvrD and DinG, that might promote replication of protein-bound DNA. One...