Amy L Upton
Overview
Explore the profile of Amy L Upton including associated specialties, affiliations and a list of published articles.
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14
Citations
517
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Recent Articles
1.
Midgley-Smith S, Dimude J, Taylor T, Forrester N, Upton A, Lloyd R, et al.
Nucleic Acids Res
. 2018 Jul;
46(15):7701-7715.
PMID: 29982635
Chromosome duplication initiates via the assembly of replication forks at defined origins. Forks proceed in opposite directions until they fuse with a converging fork. Recent work highlights that fork fusions...
2.
Nolivos S, Upton A, Badrinarayanan A, Muller J, Zawadzka K, Wiktor J, et al.
Nat Commun
. 2016 Jan;
7:10466.
PMID: 26818444
The Escherichia coli SMC complex, MukBEF, forms clusters of molecules that interact with the decatenase topisomerase IV and which are normally associated with the chromosome replication origin region (ori). Here...
3.
Dimude J, Stockum A, Midgley-Smith S, Upton A, Foster H, Khan A, et al.
mBio
. 2015 Nov;
6(6):e01294-15.
PMID: 26530381
Unlabelled: Chromosome replication is regulated in all organisms at the assembly stage of the replication machinery at specific origins. In Escherichia coli, the DnaA initiator protein regulates the assembly of...
4.
Ivanova D, Taylor T, Smith S, Dimude J, Upton A, Mehrjouy M, et al.
Nucleic Acids Res
. 2015 Jul;
43(16):7865-77.
PMID: 26160884
Each cell division requires the unwinding of millions of DNA base pairs to allow chromosome duplication and gene transcription. As DNA replication and transcription share the same template, conflicts between...
5.
Upton A, Grove J, Mahdi A, Briggs G, Milner D, Rudolph C, et al.
Nucleic Acids Res
. 2014 Apr;
42(9):5702-14.
PMID: 24692661
RecG is a DNA translocase encoded by most species of bacteria. The Escherichia coli protein targets branched DNA substrates and drives the unwinding and rewinding of DNA strands. Its ability...
6.
Nicolas E, Upton A, Uphoff S, Henry O, Badrinarayanan A, Sherratt D
mBio
. 2014 Feb;
5(1):e01001-13.
PMID: 24520061
Unlabelled: The Escherichia coli structural maintenance of chromosome (SMC) complex, MukBEF, and topoisomerase IV (TopoIV) interact in vitro through a direct contact between the MukB dimerization hinge and the C-terminal...
7.
Rudolph C, Upton A, Stockum A, Nieduszynski C, Lloyd R
Nature
. 2013 Jul;
500(7464):608-11.
PMID: 23892781
Chromosome duplication normally initiates through the assembly of replication fork complexes at defined origins. DNA synthesis by any one fork is thought to cease when it meets another travelling in...
8.
Upton A, Sherratt D
Nat Struct Mol Biol
. 2013 Mar;
20(3):246-9.
PMID: 23463306
No abstract available.
9.
Rudolph C, Mahdi A, Upton A, Lloyd R
Genetics
. 2010 Jul;
186(2):473-92.
PMID: 20647503
Replication of the Escherichia coli chromosome usually initiates at a single origin (oriC) under control of DnaA. Two forks are established and move away in opposite directions. Replication is completed...
10.
Rudolph C, Upton A, Briggs G, Lloyd R
DNA Repair (Amst)
. 2010 Jan;
9(3):210-23.
PMID: 20093100
The RecG protein of Escherichia coli is a double-stranded DNA translocase that unwinds a variety of branched DNAs in vitro, including Holliday junctions, replication forks, D-loops and R-loops. Coupled with...