Robert Coukos
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Explore the profile of Robert Coukos including associated specialties, affiliations and a list of published articles.
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10
Citations
272
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Recent Articles
1.
Coukos R, Krainc D
Nat Rev Neurosci
. 2024 Apr;
25(6):393-413.
PMID: 38600347
Parkinson disease (PD) is a neurodegenerative disorder marked by the preferential dysfunction and death of dopaminergic neurons in the substantia nigra. The onset and progression of PD is influenced by...
2.
Fokas J, Coukos R
Neurology
. 2023 Mar;
101(4):187-190.
PMID: 36878695
With the incorporation of pass/fail outcomes into the curricula of many medical schools, a greater premium is being placed on leadership, research, and other extracurricular pursuits. These activities, as well...
3.
Kim S, Coukos R, Gao F, Krainc D
Neuron
. 2022 May;
110(15):2386-2408.
PMID: 35561676
The defining evolutionary feature of eukaryotic cells is the emergence of membrane-bound organelles. Compartmentalization allows each organelle to maintain a spatially, physically, and chemically distinct environment, which greatly bolsters individual...
4.
Coukos R, Yao D, Sanchez M, Strand E, Olive M, Udeshi N, et al.
Elife
. 2021 Aug;
10.
PMID: 34414886
The trafficking of specific protein cohorts to correct subcellular locations at correct times is essential for every signaling and regulatory process in biology. Gene perturbation screens could provide a powerful...
5.
Brickner D, Randise-Hinchliff C, Lebrun Corbin M, Liang J, Kim S, Sump B, et al.
Dev Cell
. 2019 Jun;
49(6):936-947.e4.
PMID: 31211995
Loss of nuclear pore complex (NPC) proteins, transcription factors (TFs), histone modification enzymes, Mediator, and factors involved in mRNA export disrupts the physical interaction of chromosomal sites with NPCs. Conditional...
6.
Kim M, Wang W, Sanchez M, Coukos R, Von Zastrow M, Ting A
Elife
. 2017 Dec;
6.
PMID: 29189201
Transcriptional assays, such as yeast two-hybrid and TANGO, that convert transient protein-protein interactions (PPIs) into stable expression of transgenes are powerful tools for PPI discovery, screens, and analysis of cell...
7.
Brickner D, Sood V, Tutucci E, Coukos R, Viets K, Singer R, et al.
Mol Biol Cell
. 2016 Aug;
27(19):2980-93.
PMID: 27489341
On activation, the GAL genes in yeast are targeted to the nuclear periphery through interaction with the nuclear pore complex. Here we identify two cis-acting "DNA zip codes" from the...
8.
DUrso A, Takahashi Y, Xiong B, Marone J, Coukos R, Randise-Hinchliff C, et al.
Elife
. 2016 Jun;
5.
PMID: 27336723
In yeast and humans, previous experiences can lead to epigenetic transcriptional memory: repressed genes that exhibit mitotically heritable changes in chromatin structure and promoter recruitment of poised RNA polymerase II...
9.
Randise-Hinchliff C, Coukos R, Sood V, Sumner M, Zdraljevic S, Sholl L, et al.
J Cell Biol
. 2016 Mar;
212(6):633-46.
PMID: 26953353
In budding yeast, targeting of active genes to the nuclear pore complex (NPC) and interchromosomal clustering is mediated by transcription factor (TF) binding sites in the gene promoters. For example,...
10.
Brickner D, Coukos R, Brickner J
Microb Cell
. 2015 Dec;
2(12):481-490.
PMID: 26688804
Many genes localize at the nuclear periphery through physical interaction with the nuclear pore complex (NPC). We have found that the yeast gene is targeted to the NPC both upon...