Jason H Brickner
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Explore the profile of Jason H Brickner including associated specialties, affiliations and a list of published articles.
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2061
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Recent Articles
1.
Ge T, Brickner D, Zehr K, VanBelzen D, Zhang W, Caffalette C, et al.
Mol Cell
. 2025 Mar;
PMID: 40068679
Nuclear pore proteins (nucleoporins [Nups]) physically interact with hundreds of chromosomal sites, impacting transcription. In yeast, transcription factors mediate interactions between Nups and enhancers and promoters. To define the molecular...
2.
VanBelzen J, Sakelaris B, Brickner D, Marcou N, Riecke H, Mangan N, et al.
Elife
. 2024 Nov;
13.
PMID: 39607887
Chromatin immunoprecipitation (ChIP-seq) is the most common approach to observe global binding of proteins to DNA in vivo. The occupancy of transcription factors (TFs) from ChIP-seq agrees well with an...
3.
VanBelzen J, Sakelaris B, Brickner D, Marcou N, Riecke H, Mangan N, et al.
bioRxiv
. 2024 Jul;
PMID: 39026809
Chromatin immunoprecipitation (ChIP-seq) is the most common approach to observe global binding of proteins to DNA . The occupancy of transcription factors (TFs) from ChIP-seq agrees well with an alternative...
4.
Ge T, Brickner D, Zehr K, VanBelzen D, Zhang W, Caffalette C, et al.
bioRxiv
. 2024 May;
PMID: 38798450
Nuclear pore proteins (Nups) in yeast, flies and mammals physically interact with hundreds or thousands of chromosomal sites, which impacts transcriptional regulation. In budding yeast, transcription factors mediate interaction of...
5.
Ge T, Brickner J
Curr Opin Genet Dev
. 2024 Mar;
85:102174.
PMID: 38430840
Epigenetic memory allows organisms to stably alter their transcriptional program in response to developmental or environmental stimuli. Such transcriptional programs are mediated by heritable regulation of the function of enhancers...
6.
VanBelzen J, Duan C, Brickner D, Brickner J
NAR Genom Bioinform
. 2024 Feb;
6(1):lqae012.
PMID: 38327869
Defining the DNA binding specificity of transcription factors (TFs) has relied nearly exclusively on chromatin immunoprecipitation (ChIP). While ChIP reveals TF binding patterns, its resolution is low. Higher resolution methods...
7.
VanBelzen J, Duan C, Brickner D, Brickner J
bioRxiv
. 2023 Oct;
PMID: 37905156
Defining the DNA binding specificity of transcription factors (TFs) has relied nearly exclusively on chromatin immunoprecipitation (ChIP). While ChIP reveals TF binding patterns, its resolution is low. Higher resolution methods...
8.
Brickner J
J Cell Biol
. 2023 Aug;
222(9).
PMID: 37603083
The nuclear pore complex (NPC) both mediates exchange of proteins and RNA between the nucleus and the cytoplasm and physically interacts with chromatin to regulate transcription. In this issue of...
9.
Brickner J
Ann N Y Acad Sci
. 2023 Jun;
1526(1):50-58.
PMID: 37391188
Epigenetic transcriptional regulation frequently requires histone modifications. Some, but not all, of these modifications are able to template their own inheritance. Here, I discuss the molecular mechanisms by which histone...
10.
Sump B, Brickner D, DUrso A, Kim S, Brickner J
Elife
. 2022 May;
11.
PMID: 35579426
For some inducible genes, the rate and molecular mechanism of transcriptional activation depend on the prior experiences of the cell. This phenomenon, called epigenetic transcriptional memory, accelerates reactivation, and requires...