Robert Castelo
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Explore the profile of Robert Castelo including associated specialties, affiliations and a list of published articles.
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28
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10357
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Recent Articles
1.
Boll L, Vazquez Montes de Oca S, Camarena M, Castelo R, Bellmunt J, Perera-Bel J, et al.
Nat Commun
. 2025 Feb;
16(1):1213.
PMID: 39979258
Advanced bladder cancer patients show very variable responses to immune checkpoint inhibitors (ICIs) and effective strategies to predict response are still lacking. Here we integrate mutation and gene expression data...
2.
Camarena M, Theunissen P, Ruiz M, Ruiz-Orera J, Calvo-Serra B, Castelo R, et al.
Sci Adv
. 2024 Jul;
10(28):eadn3628.
PMID: 38985879
The expression of tumor-specific antigens during cancer progression can trigger an immune response against the tumor. Here, we investigate if microproteins encoded by noncanonical open reading frames (ncORFs) are a...
3.
Costa D, Bonet N, Sole A, Gonzalez de Aledo-Castillo J, Sabido E, Casals F, et al.
FEBS J
. 2020 Oct;
288(7):2311-2331.
PMID: 33006196
The fetal inflammatory response (FIR) increases the risk of perinatal brain injury, particularly in extremely low gestational age newborns (ELGANs, < 28 weeks of gestation). One of the mechanisms contributing...
4.
Puigdevall P, Piccari L, Blanco I, Barbera J, Geiger D, Badenas C, et al.
J Med Genet
. 2019 Mar;
56(7):481-490.
PMID: 30894412
Background: Mapping the genetic component of molecular mechanisms responsible for the reduced penetrance (RP) of rare disorders constitutes one of the most challenging problems in human genetics. Heritable pulmonary arterial...
5.
Gea J, Pascual S, Castro-Acosta A, Hernandez-Carcereny C, Castelo R, Marquez-Martin E, et al.
Arch Bronconeumol (Engl Ed)
. 2018 Oct;
55(2):93-99.
PMID: 30343952
Chronic obstructive pulmonary disease (COPD) is an entity with a heterogeneous presentation. For this reason, attempts have been made to characterize different phenotypes and endotypes to enable a more individualized...
6.
Puigdevall P, Castelo R
Bioinformatics
. 2018 May;
34(18):3208-3210.
PMID: 29718111
Summary: Genomewide position-specific scores, such as those estimating conservation, constraint, fitness or mutation tolerance, are ubiquitous in current genome analyses. The diversity of sources and formats of these scores, as...
7.
Hanzelmann S, Wang J, Guney E, Tang Y, Zhang E, Axelsson A, et al.
Islets
. 2016 Jan;
7(4):e1118195.
PMID: 26742564
The disease mechanisms underlying type 2 diabetes (T2D) remain poorly defined. Here we aimed to explore the pathophysiology of T2D by analyzing gene co-expression networks in human islets. Using partial...
8.
Baumstark R, Hanzelmann S, Tsuru S, Schaerli Y, Francesconi M, Mancuso F, et al.
Nat Commun
. 2015 Dec;
6:10105.
PMID: 26670742
What happens to gene expression when you add new links to a gene regulatory network? To answer this question, we profile 85 network rewirings in E. coli. Here we report...
9.
Costa D, Castelo R
Pediatr Res
. 2015 Nov;
79(3):473-81.
PMID: 26539667
Background: The fetal inflammatory response (FIR) in placental membranes to an intrauterine infection often precedes premature birth raising neonatal mortality and morbidity. However, the precise molecular events behind FIR still...
10.
Kannan L, Ramos M, Re A, El-Hachem N, Safikhani Z, Gendoo D, et al.
Brief Bioinform
. 2015 Oct;
17(4):603-15.
PMID: 26463000
Molecular interrogation of a biological sample through DNA sequencing, RNA and microRNA profiling, proteomics and other assays, has the potential to provide a systems level approach to predicting treatment response...