Robert C Onofrio
Overview
Explore the profile of Robert C Onofrio including associated specialties, affiliations and a list of published articles.
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20
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17105
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Recent Articles
1.
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin A, Kim S, et al.
Nature
. 2018 Dec;
565(7738):E5-E6.
PMID: 30559381
No abstract available.
2.
Baca S, Prandi D, Lawrence M, Mosquera J, Romanel A, Drier Y, et al.
Cell
. 2013 Apr;
153(3):666-77.
PMID: 23622249
The analysis of exonic DNA from prostate cancers has identified recurrently mutated genes, but the spectrum of genome-wide alterations has not been profiled extensively in this disease. We sequenced the...
3.
Dulak A, Stojanov P, Peng S, Lawrence M, Fox C, Stewart C, et al.
Nat Genet
. 2013 Mar;
45(5):478-86.
PMID: 23525077
The incidence of esophageal adenocarcinoma (EAC) has risen 600% over the last 30 years. With a 5-year survival rate of ~15%, the identification of new therapeutic targets for EAC is...
4.
Hodis E, Watson I, Kryukov G, Arold S, Imielinski M, Theurillat J, et al.
Cell
. 2012 Jul;
150(2):251-63.
PMID: 22817889
Despite recent insights into melanoma genetics, systematic surveys for driver mutations are challenged by an abundance of passenger mutations caused by carcinogenic UV light exposure. We developed a permutation-based framework...
5.
Banerji S, Cibulskis K, Rangel-Escareno C, Brown K, Carter S, Frederick A, et al.
Nature
. 2012 Jun;
486(7403):405-9.
PMID: 22722202
Breast carcinoma is the leading cause of cancer-related mortality in women worldwide, with an estimated 1.38 million new cases and 458,000 deaths in 2008 alone. This malignancy represents a heterogeneous...
6.
Barbieri C, Baca S, Lawrence M, Demichelis F, Blattner M, Theurillat J, et al.
Nat Genet
. 2012 May;
44(6):685-9.
PMID: 22610119
Prostate cancer is the second most common cancer in men worldwide and causes over 250,000 deaths each year. Overtreatment of indolent disease also results in significant morbidity. Common genetic alterations...
7.
Carter S, Cibulskis K, Helman E, McKenna A, Shen H, Zack T, et al.
Nat Biotechnol
. 2012 May;
30(5):413-21.
PMID: 22544022
We describe a computational method that infers tumor purity and malignant cell ploidy directly from analysis of somatic DNA alterations. The method, named ABSOLUTE, can detect subclonal heterogeneity and somatic...
8.
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin A, Kim S, et al.
Nature
. 2012 Mar;
483(7391):603-7.
PMID: 22460905
The systematic translation of cancer genomic data into knowledge of tumour biology and therapeutic possibilities remains challenging. Such efforts should be greatly aided by robust preclinical model systems that reflect...
9.
Hammerman P, Sos M, Ramos A, Xu C, Dutt A, Zhou W, et al.
Cancer Discov
. 2012 Feb;
1(1):78-89.
PMID: 22328973
Unlabelled: While genomically targeted therapies have improved outcomes for patients with lung adenocarcinoma, little is known about the genomic alterations which drive squamous cell lung cancer. Sanger sequencing of the...
10.
Cho J, Pastorino S, Zeng Q, Xu X, Johnson W, Vandenberg S, et al.
Cancer Res
. 2011 Oct;
71(24):7587-96.
PMID: 22001862
Genomic alterations of the epidermal growth factor receptor (EGFR) gene play a crucial role in pathogenesis of glioblastoma multiforme (GBM). By systematic analysis of GBM genomic data, we have identified...