Kristian Cibulskis
Overview
Explore the profile of Kristian Cibulskis including associated specialties, affiliations and a list of published articles.
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61
Citations
55197
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Recent Articles
1.
Gudmundsson S, Karczewski K, Francioli L, Tiao G, Cummings B, Alfoldi J, et al.
Nature
. 2021 Aug;
597(7874):E3-E4.
PMID: 34373650
No abstract available.
2.
Karczewski K, Francioli L, Tiao G, Cummings B, Alfoldi J, Wang Q, et al.
Nature
. 2021 Feb;
590(7846):E53.
PMID: 33536625
No abstract available.
3.
Karczewski K, Francioli L, Tiao G, Cummings B, Alfoldi J, Wang Q, et al.
Nature
. 2020 May;
581(7809):434-443.
PMID: 32461654
Genetic variants that inactivate protein-coding genes are a powerful source of information about the phenotypic consequences of gene disruption: genes that are crucial for the function of an organism will...
4.
Johnson C, Kim I, Esmaeli B, Amin-Mansour A, Treacy D, Carter S, et al.
PLoS One
. 2017 Jun;
12(6):e0178189.
PMID: 28594900
To further our understanding of the somatic genetic basis of uveal melanoma, we sequenced the protein-coding regions of 52 primary tumors and 3 liver metastases together with paired normal DNA....
5.
Burger J, Landau D, Taylor-Weiner A, Bozic I, Zhang H, Sarosiek K, et al.
Nat Commun
. 2016 May;
7:11589.
PMID: 27199251
Resistance to the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib has been attributed solely to mutations in BTK and related pathway molecules. Using whole-exome and deep-targeted sequencing, we dissect evolution of...
6.
Landau D, Tausch E, Taylor-Weiner A, Stewart C, Reiter J, Bahlo J, et al.
Nature
. 2015 Oct;
526(7574):525-30.
PMID: 26466571
Which genetic alterations drive tumorigenesis and how they evolve over the course of disease and therapy are central questions in cancer biology. Here we identify 44 recurrently mutated genes and...
7.
Brastianos P, Carter S, Santagata S, Cahill D, Taylor-Weiner A, Jones R, et al.
Cancer Discov
. 2015 Sep;
5(11):1164-1177.
PMID: 26410082
Unlabelled: Brain metastases are associated with a dismal prognosis. Whether brain metastases harbor distinct genetic alterations beyond those observed in primary tumors is unknown. We performed whole-exome sequencing of 86...
8.
Shukla S, Rooney M, Rajasagi M, Tiao G, Dixon P, Lawrence M, et al.
Nat Biotechnol
. 2015 Sep;
33(11):1152-8.
PMID: 26372948
Detection of somatic mutations in human leukocyte antigen (HLA) genes using whole-exome sequencing (WES) is hampered by the high polymorphism of the HLA loci, which prevents alignment of sequencing reads...
9.
Brat D, Verhaak R, Aldape K, Yung W, Salama S, Cooper L, et al.
N Engl J Med
. 2015 Jun;
372(26):2481-98.
PMID: 26061751
Background: Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior that is not adequately predicted...
10.
van de Wetering M, Francies H, Francis J, Bounova G, Iorio F, Pronk A, et al.
Cell
. 2015 May;
161(4):933-45.
PMID: 25957691
In Rspondin-based 3D cultures, Lgr5 stem cells from multiple organs form ever-expanding epithelial organoids that retain their tissue identity. We report the establishment of tumor organoid cultures from 20 consecutive...