Robert C Mettelman
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Explore the profile of Robert C Mettelman including associated specialties, affiliations and a list of published articles.
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21
Citations
774
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Recent Articles
1.
Schattgen S, Turner J, Ghonim M, Crawford J, Schmitz A, Kim H, et al.
Nat Immunol
. 2024 Aug;
25(9):1742-1753.
PMID: 39164477
The differentiation and specificity of human CD4 T follicular helper cells (T cells) after influenza vaccination have been poorly defined. Here we profiled blood and draining lymph node (LN) samples...
2.
Jia X, Crawford J, Gebregzabher D, Monson E, Mettelman R, Wan Y, et al.
Cell
. 2024 Aug;
187(17):4586-4604.e20.
PMID: 39137778
Respiratory infections cause significant morbidity and mortality, yet it is unclear why some individuals succumb to severe disease. In patients hospitalized with avian A(H7N9) influenza, we investigated early drivers underpinning...
3.
Bodansky A, Mettelman R, Sabatino Jr J, Vazquez S, Chou J, Novak T, et al.
Nature
. 2024 Aug;
632(8025):622-629.
PMID: 39112696
Multisystem inflammatory syndrome in children (MIS-C) is a severe, post-infectious sequela of SARS-CoV-2 infection, yet the pathophysiological mechanism connecting the infection to the broad inflammatory syndrome remains unknown. Here we...
4.
Kirk A, Crawford J, Chou C, Guy C, Pandey K, Kozlik T, et al.
Cell Rep Med
. 2024 Mar;
5(3):101469.
PMID: 38508137
Fibrolamellar carcinoma (FLC) is a liver tumor with a high mortality burden and few treatment options. A promising therapeutic vulnerability in FLC is its driver mutation, a conserved DNAJB1-PRKACA gene...
5.
Mettelman R, Souquette A, Van de Velde L, Vegesana K, Allen E, Kackos C, et al.
Nat Immunol
. 2023 Aug;
24(9):1511-1526.
PMID: 37592015
Evidence suggests that innate and adaptive cellular responses mediate resistance to the influenza virus and confer protection after vaccination. However, few studies have resolved the contribution of cellular responses within...
6.
Cable J, Balachandran S, Daley-Bauer L, Rustagi A, Antony F, Frere J, et al.
Ann N Y Acad Sci
. 2023 Jan;
1521(1):32-45.
PMID: 36718537
Viruses infect millions of people each year. Both endemic viruses circulating throughout the population as well as novel epidemic and pandemic viruses pose ongoing threats to global public health. Developing...
7.
Pogorelyy M, Rosati E, Minervina A, Mettelman R, Scheffold A, Franke A, et al.
Cell Rep Med
. 2022 Jul;
3(8):100697.
PMID: 35841887
The current strategy to detect immunodominant T cell responses focuses on the antigen, employing large peptide pools to screen for functional cell activation. However, these approaches are labor and sample...
8.
Wilson T, Kim H, Chou C, Langfitt D, Mettelman R, Minervina A, et al.
Cancer Discov
. 2022 Jul;
12(9):2098-2119.
PMID: 35792801
Significance: Utilizing clonal trajectories to define transcriptional potential, we find a unique signature of CAR T-cell effector precursors present in preinfusion cell products. Functional assessment of cells with this signature...
9.
Mettelman R, Allen E, Thomas P
Immunity
. 2022 May;
55(5):749-780.
PMID: 35545027
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive immune responses in the respiratory tract are...
10.
Minervina A, Pogorelyy M, Kirk A, Crawford J, Allen E, Chou C, et al.
Nat Immunol
. 2022 Apr;
23(5):781-790.
PMID: 35383307
Although mRNA vaccine efficacy against severe coronavirus disease 2019 remains high, variant emergence has prompted booster immunizations. However, the effects of repeated exposures to severe acute respiratory syndrome coronavirus 2...